NCT01818401

Brief Summary

Over 70.000 total knee arthroplasty (TKA) are performed in France every year, with a 10% yearly increase since the early 1990s. The clinical experience shows a strong rate of success on pain relief and on function. Longevity of the implants has been shown to be determined by the biomechanical design of the prosthesis, and by the implantation technique, especially the correct positioning of the bone cuts during the surgery. To improve the precision of these cuts, the patient matched cutting blocks developed by Medacta allow to adapt the bone cuts to the patient's anatomy, improving the reliability of this procedure. A reduction of the surgery time lengh and bleeding would be other benefits expected with this type of ancillary. The objective of this trial is to study the reliability of patient matched cutting blocks for total knee arthroplasty, by both clinical and radiological assessment, the effect on morbidity reduction during and after the procedure and also the benefit it could bring on an economic point of view.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
95

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Mar 2013

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2013

Completed
20 days until next milestone

First Submitted

Initial submission to the registry

March 21, 2013

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 26, 2013

Completed
3.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2016

Completed
8.8 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2025

Completed
Last Updated

October 9, 2017

Status Verified

October 1, 2017

Enrollment Period

3.8 years

First QC Date

March 21, 2013

Last Update Submit

October 6, 2017

Conditions

Keywords

Ancillary tailoredmedico-economic study,total knee replacementprimary or secondary osteoarthritis

Outcome Measures

Primary Outcomes (1)

  • compare the functionality of the knee after installation of a total knee replacement between the 2 groups

    The evaluation will use a specific score for total knee arthroplasty: Part of the Knee Society function score (KSS) measured at 1 year after surgery.

    2 years after

Secondary Outcomes (2)

  • to assess knee function by autoquestionnaire KOOS, the KSS knee score, operative time, procedure bleeding, reliability of the ancillary

    2 years after

  • medico-economic evaluation type "Cost minimization"

    2 years after

Study Arms (2)

Control group

OTHER

The control group will be constituted of patients with the prosthesis GMK ® without the ancillary MyKnee ® LBS.

Device: the prosthesis GMK ® without the ancillary MyKnee ® LBS

Matched patient

OTHER

The treated group will consist of patients which the GMK ® prosthesis with ancillary ® MyKnee LBS.

Device: Matched patient cutting blocks MyKnee ® LBS

Interventions

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • all patients requiring a total knee arthroplasty line: primary or secondary osteoarthritis advanced beyond medical treatment.

You may not qualify if:

  • distorded axes or laxity requiring the establishment of constrained prosthesis

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University Hospital of Nantes

Nantes, 44000, France

Location

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 21, 2013

First Posted

March 26, 2013

Study Start

March 1, 2013

Primary Completion

December 1, 2016

Study Completion

September 1, 2025

Last Updated

October 9, 2017

Record last verified: 2017-10

Locations