Cerebral Reorganization in Schizophrenia
Training-induced Cerebral Reorganization in Schizophrenia
1 other identifier
interventional
80
1 country
1
Brief Summary
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable schizophrenia
Started Dec 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2011
CompletedFirst Submitted
Initial submission to the registry
January 22, 2013
CompletedFirst Posted
Study publicly available on registry
January 31, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2014
CompletedNovember 4, 2014
November 1, 2014
2.3 years
January 22, 2013
November 3, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
change from baseline at post-intervention (4-weeks) and 3-months in each to the primary outcome measures: neuropsychological test scores (MCCB), MEG alpha oscillations
baseline, post-intervention (after 4 weeks), 3-months follow-up
Secondary Outcomes (1)
change from baseline in global functioning (GAF score) at 4 weeks and 3 months
baseline, post-intervention, 3-months follow-up
Study Arms (3)
Auditiory verbal discrimination training
EXPERIMENTALBrain Fitness \& Brain Training- Posit Science
Facial affect discrimination training
EXPERIMENTALBehavioral: Facial Affect Training- FAT
Treatment as usual
ACTIVE COMPARATORstandard treatment/rehabilitation protocol of schizophrenia ward
Interventions
Computer aided cognitive program designed for intensive training of auditory perception, memory and attention
Computer-aided cognitive program designed for intensive training of facial affect discrimination, memory and attention
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of schizophrenia and disorders with psychotic features
- Intact auditory perception
- Intact visual perception
You may not qualify if:
- Mental retardation
- Age over 60
- Insufficient German language knowledge
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of Konstanz
Konstanz, Baden-Wurttemberg, 78464, Germany
Related Publications (1)
Popova P, Popov TG, Wienbruch C, Carolus AM, Miller GA, Rockstroh BS. Changing facial affect recognition in schizophrenia: effects of training on brain dynamics. Neuroimage Clin. 2014 Sep 4;6:156-65. doi: 10.1016/j.nicl.2014.08.026. eCollection 2014.
PMID: 25379427BACKGROUND
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Brigitte Rockstroh, Prof. Dr.
University Konstanz
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Prof. Dr.
Study Record Dates
First Submitted
January 22, 2013
First Posted
January 31, 2013
Study Start
December 1, 2011
Primary Completion
April 1, 2014
Study Completion
April 1, 2014
Last Updated
November 4, 2014
Record last verified: 2014-11