NCT01780363

Brief Summary

Background: Genetics is suggested to play a critical role in the development of Behçet's disease (BD). Shared phenotypic features requires an approach to the differential diagnosis from periodic febrile syndromes particularly from mevalonate kinase deficiency related diseases. We planned to study for evaluating the frequency of mutations and their clinical significance in mevalonate kinase gene in Turkish patients with Behçet's disease.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2011

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2011

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

January 29, 2013

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 31, 2013

Completed
Last Updated

January 31, 2013

Status Verified

January 1, 2011

Enrollment Period

11 months

First QC Date

January 29, 2013

Last Update Submit

January 29, 2013

Conditions

Behçet's Disease

Outcome Measures

Primary Outcomes (1)

  • Frequency of mevalonate kinase frequency in Behçet disease

    One year

Secondary Outcomes (1)

  • Mevalonate kinase gene and clinical correlations in Behçet's disease

    One year

Study Arms (2)

controls

frequency of mevalonate kinase gene frequency

Behçet patients

frequency of mevalonate kinase gene mutations

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Turkish kindred

You may qualify if:

  • Behçet patients

You may not qualify if:

  • Diagnosis of periodic fever syndromes

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Cukurova University

Adana, 01330, Turkey (Türkiye)

Location

Didem Arslan Tas

Adana, 01330, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Behcet Syndrome

Condition Hierarchy (Ancestors)

Mouth DiseasesStomatognathic DiseasesUveitis, AnteriorPanuveitisUveitisUveal DiseasesEye DiseasesVasculitisVascular DiseasesCardiovascular DiseasesHereditary Autoinflammatory DiseasesGenetic Diseases, InbornCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesSkin Diseases, GeneticSkin DiseasesSkin and Connective Tissue DiseasesSkin Diseases, Vascular

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

January 29, 2013

First Posted

January 31, 2013

Study Start

January 1, 2011

Primary Completion

December 1, 2011

Last Updated

January 31, 2013

Record last verified: 2011-01

Locations

TU(2)