The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's Disease

NCT01720628 | Completed DMC

• 1 other identifier: AFV-5813
• Study Type: observational
• Target: 86
• Locations: 1 country
• Sites: 1

Brief Summary

Objectives: Behçet's disease (BD) is a systemic vasculitis. Since vascular endothelial dysfunction plays a prominent role in the pathogenesis of the disease, we considered angiogenic cytokines as an interesting target for investigation in BD. The aim of this study was to investigate the possible role of angiogenin, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD. Design and Methods: Sixty five patients with BD and 21 healthy control subjects were included in the study. Serum angiogenin, bFGF and VEGF concentrations were determined by using in vitro enzyme immunoassay (ELISA) kits according to the manufacturer's instructions.

Conditions

Behçet's Disease

Keywords

Angiogenin, Behçet's disease, bFGF, VEGF

Outcome Measures

Primary Outcomes (1)

• Serum levels of angiogenin in Behçet's patients with or without ocular involvement

  The median serum angiogenin level was significantly higher in all patients with BD than controls (P=0.001). However there was no statistically significant difference between all patients and patients with or without ocular involvement. The mean serum bFGF and the median serum VEGF levels were higher in patients with ocular involvement than all patients, patients without ocular involvement and controls. But these differences did not reach statistical significance.

  1 year

Secondary Outcomes (1)

• Serum levels of bFGF in Behçet's patients with or without ocular involvement

  1 year

Other Outcomes (1)

• Serum levels of VEGF in Behçet's patients with or without ocular involvement

  1 year

Study Arms (1)

Behçet's patients

Serum levels of angiogenin, bFGF, VEGF levels in Behçet's patients with ocular involvement group, without ocular involvement group and control group

Other: serum levels of angiogenin, bFGF, VEGF

Interventions

serum levels of angiogenin, bFGF, VEGF OTHER

Behçet's patients

Behçet's patients

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Turkish patients fulfilling the international diagnostic criteria for Behçet's disease

You may qualify if:

• age between 18-65
• fulfilling the international diagnostic criteria for Behçet's disease

You may not qualify if:

• to have another systemic disease

Sponsors & Collaborators

• Turkish Ophthalmology Society: lead

Study Sites (1)

Ankara University, Faculty of Medicine, Department of Ophthalmology

Ankara, 06620, Turkey (Türkiye)

Location

Biospecimen

Retention: SAMPLES WITH DNA

serum

MeSH Terms

Conditions

Behcet Syndrome

Interventions

Vascular Endothelial Growth Factor A

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases; Uveitis, Anterior; Panuveitis; Uveitis; Uveal Diseases; Eye Diseases; Vasculitis; Vascular Diseases; Cardiovascular Diseases; Hereditary Autoinflammatory Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin Diseases, Genetic; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Vascular

Intervention Hierarchy (Ancestors)

Vascular Endothelial Growth Factors; Angiogenic Proteins; Intercellular Signaling Peptides and Proteins; Peptides; Amino Acids, Peptides, and Proteins; Proteins; Biological Factors

Study Officials

• ali yalçındağ

  * Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Clinical Biochemistry

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: October 23, 2012
• First Posted: November 2, 2012
• Study Start: November 1, 2011
• Primary Completion: November 1, 2011
• Study Completion: February 1, 2012
• Last Updated: November 2, 2012

Record last verified: 2012-10

Locations

TU (1)