South Asian Yoga and Exercise Trial

NCT01766453 | Completed

• 1 other identifier: SFU
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

South Asians have one of the highest rates of heart disease of all populations and a unique and deleterious obesity phenotype of increased body fat and inner-abdominal compared to those of European background. We have subsequently identified that this unique phenotype accounts for much of the increased heart disease risk in South Asians, with the greater amounts of inner abdominal fat being particularly implicated. In addition, South Asians in Canada have substantially lower levels of leisure-time physical activity. At present, we do not know the answers to the following questions:

1. 1.Is a conventional (standard) physical activity program that has proven effective at reducing inner abdominal fat and heart disease risk factors in populations of European background be effective in South Asians?
2. 2.Is an alternative physical activity program commonly practiced by South Asians (such as bhangra dance) be effective at reducing inner abdominal fat and heart disease risk factors in South Asians? In this study, we will perform a randomized controlled trial of three conditions-gym-based standard exercise program (SE),bhangra dance exercise program (BE) and non-exercise control (NE).We will recruit 75 post-menopausal South Asian women with abdominal obesity and assign them randomly to one of the three groups (25 per group).

Conditions

Obesity

Keywords

South Asian; Cardiovascular; Exercise; Obesity; Visceral Adipose Tissue

Outcome Measures

Primary Outcomes (1)

• Visceral adipose tissue

  Visceral adipose tissue will be assessed with multi-slice computed tomography

  12 weeks

Secondary Outcomes (3)

• Cardiometabolic risk factors

  12 weeks

• Body Composition

  12 weeks

• Maximal Aerobic Fitness

  12 weeks

Study Arms (3)

Non exercise control

NO INTERVENTION

Non exercise control will undergo baseline testing and follow up testing but will not participate in an exercise intervention.

Standard Exercise

EXPERIMENTAL

The standard exercise group will attend exercise sessions under the supervision of a Certified Personal Trainer. Intensity will increase every four weeks by 10% from 50-80% of maximal heart rate to ensure that exercise is progressive in nature. Participants will be provided with a heart rate monitor during their exercise sessions and have the option to perform the aerobic training on a treadmill, upright bike, elliptical machine or recumbent bike as long as heart rate is kept within the prescribed training intensity. Intensity, duration, resting and exercise heart rates will be recorded for each exercise session for the duration of the intervention to ensure compliance to the exercise program.

Behavioral: Standard Exercise

Bhangra Dance Exercise

EXPERIMENTAL

Bhangra dance classes taught be a certified instructor progressing in difficulty over the 12 week period. Bhangra dance is an Indian folk dance that consists of jumping and kicking of a high intensity. This group will attend exercise sessions under the supervision of a Bhangra Dance Instructor. The intensity of bhangra dance will be tracked through heart rate monitors worn by participants.

Behavioral: Bhangra dance exercise

Interventions

Standard Exercise BEHAVIORAL

Aerobic exercise with a progressive increase in intensity over 12 weeks.

Standard Exercise

Bhangra dance exercise BEHAVIORAL

Bhangra Dance classes taught by an instructor.

Bhangra Dance Exercise

Eligibility Criteria

• Age: 45 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Post-menopausal South Asian women defined as not menstruating for the previous 12 consecutive months as assessed by self report
• Waist circumference \>80 cm (women), as identified as South Asian cut offs by International Diabetes Federation109
• Able to read and write and understand English
• Previously sedentary (\<150 minutes of physical activity per week as assessed by accelerometry)
• Weight stable (\<2kg of weight change over the past 6 weeks)

You may not qualify if:

• Taking medication that may affect study outcomes (lipid-lowering, antihypertensive, or hypoglycemic medications)
• Unable to provide informed consent
• Individuals \> 136 kg (physical limitation of DXA scanner table)
• Smokers (given the confounding association between smoking and adiposity)
• Unable to participate in exercise sessions due to physical limitations or contra-indications to regular exercise as indicated on the baseline maximal exercise stress test
• Individuals with known CVD or other known comorbidities (HIV, immune compromised condition, type 1 or 2 diabetes mellitus)
• Another member of the household already participating in study

Sponsors & Collaborators

• Simon Fraser University: lead

Study Sites (1)

Simon Fraser University

Vancouver, British Columbia, V6B5K3, Canada

Location

Related Publications (1)

• Lesser IA, Singer J, Hoogbruin A, Mackey DC, Katzmarzyk PT, Sohal P, Leipsic J, Lear SA. Effectiveness of Exercise on Visceral Adipose Tissue in Older South Asian Women. Med Sci Sports Exerc. 2016 Jul;48(7):1371-8. doi: 10.1249/MSS.0000000000000906.

  PMID: 26909531 DERIVED

MeSH Terms

Conditions

Obesity; Motor Activity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Study Officials

• Scott A Lear, PhD

  Simon Fraser University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 11, 2012
• First Posted: January 11, 2013
• Study Start: April 1, 2013
• Primary Completion: November 1, 2014
• Study Completion: November 1, 2014
• Last Updated: May 20, 2015

Record last verified: 2015-05

Locations

CA (1)