NCT01745016

Brief Summary

Beta-alanine, as a method to increase muscle carnosine, has been shown to enhance muscle buffering capacity and delay fatigue. Various fatigue tests have been utilized to examine the effectiveness of beta-alanine supplementation. The physical working capacity test has been used to show significant increases in physical working capacities following supplementation. The physical working capacity tests were originally developed by Moritani et al. 1981 and Devries et al. 1982 to measure the point of onset of muscular fatigue. It is hypothesized that beta-alanine will increase physical working capacity at heart rate threshold, thereby signifying a delay in fatigue.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
35

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jan 2013

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

December 5, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

December 7, 2012

Completed
25 days until next milestone

Study Start

First participant enrolled

January 1, 2013

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2013

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2013

Completed
Last Updated

April 30, 2013

Status Verified

April 1, 2013

Enrollment Period

3 months

First QC Date

December 5, 2012

Last Update Submit

April 29, 2013

Conditions

ExerciseFatigue

Keywords

dietary supplementcarnosine

Outcome Measures

Primary Outcomes (1)

  • Physical working capacity at heart rate threshold

    0 to 4 weeks

Study Arms (2)

Placebo

PLACEBO COMPARATOR

placebo

Dietary Supplement: Placebo

Beta-Alanine

EXPERIMENTAL

beta-alanine

Dietary Supplement: Beta-alanine

Interventions

PlaceboDIETARY_SUPPLEMENT
Placebo
Beta-alanineDIETARY_SUPPLEMENT
Beta-Alanine

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Between the ages of 18-35 years old
  • Be recreationally active (defined as accumulating 1-5 hours of moderate intensity

You may not qualify if:

  • Any health risks or indicators that would prevent them from participating in physical activity, as determined by a health history questionnaire
  • Must not have taken performance enhancing supplements containing beta-alanine or creatine during the last 3 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UNC Exercise and Sport Science

Chapel Hill, North Carolina, 27599, United States

Location

MeSH Terms

Conditions

Motor ActivityFatigue

Interventions

beta-Alanine

Condition Hierarchy (Ancestors)

BehaviorSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

AlanineAmino AcidsAmino Acids, Peptides, and Proteins

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

December 5, 2012

First Posted

December 7, 2012

Study Start

January 1, 2013

Primary Completion

April 1, 2013

Study Completion

April 1, 2013

Last Updated

April 30, 2013

Record last verified: 2013-04

Locations

US(1)