NCT01744041|CompletedResultsDMC
Mommy-Baby Treatment for Perinatal Depression
Perinatal Depression: Dyadic-IPT to Improve Health of Mother and Baby
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Sponsor study identifier
Secondary identifiers
NIH
interventional
42
1 country
1
Study Start
November 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
January 31, 2017
Actual (reported)Study Completion
January 31, 2017
Actual (reported)Perinatal depression is a major public health problem, affecting 15% of women during pregnancy through the postpartum period, with adverse consequences for the mother, the fetus, the infant, and the family. Despite increasing evidence of the importance of this critical risk interval, little research has investigated the effects of depression treatment during pregnancy on infant outcomes. The purpose of this study is to test the feasibility, acceptability, and effectiveness of a new intervention, Interpersonal psychotherapy for the mother-infant dyad (IPT-Dyad). This intervention begins during pregnancy and continues with the mother and infant until one year postpartum. The investigators hypothesize that IPT-Dyad will be better than treatment as usual in reducing depressive symptoms, improving psychosocial functioning,increasing parenting self-efficacy, improving infant emotional development, and enhancing mother-infant relationship quality.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 31, 2017
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 2012
Date type not reportedThis date has not been verified as actual or estimated.
November 27, 2012
Actual (reported)December 6, 2012
Actual (reported)January 31, 2017
Actual (reported)January 31, 2017
Actual (reported)January 11, 2022
Actual (reported)Change in Edinburgh Depression Scale From Baseline
Edinburgh Postnatal Depression Scale, a 10-item scale of depression severity, scores range from 0 to 30 with higher scores indicating worse outcome.
Change from baseline at End of pregnancy (between 37-39 weeks gestation); change from baseline at 3 months postpartum; change from baseline at 6 months postpartum; change from baseline at 9 months postpartum; change from baseline at 12 months postpartum
Brief Interpersonal Psychotherapy during pregnancy followed by dyadic mother-infant psychotherapy for one year postpartum
Personalized referral to community resources for depression treatment
This intervention consists of a brief psychotherapeutic intervention, Interpersonal Psychotherapy, during pregnancy. Interpersonal Psychotherapy focuses on improving social relationships and interpersonal communication to improve mood. The postpartum phase also utilizes developmentally appropriate strategies to improve the mother-infant relationship.
This intervention consists of personalized referrals to specialty mental health providers, spiritual counselors, or other needed social services. It includes some non-specific supportive techniques delivered primarily via telephone.
Washington University School of Medicine
St Louis, Missouri, 63110, United States
Lenze SN, Rodgers J, Luby J. A pilot, exploratory report on dyadic interpersonal psychotherapy for perinatal depression. Arch Womens Ment Health. 2015 Jun;18(3):485-91. doi: 10.1007/s00737-015-0503-6. Epub 2015 Jan 22.
Lenze SN, Potts MA. Brief Interpersonal Psychotherapy for depression during pregnancy in a low-income population: A randomized controlled trial. J Affect Disord. 2017 Mar 1;210:151-157. doi: 10.1016/j.jad.2016.12.029. Epub 2016 Dec 20.
This is a small pilot study designed to assess feasibility and not efficacy of this intervention. The primary outcome measure was a self-report scale that may not reflect unbiased outcomes. There was a substantial drop-out rate in each study arm.
Shannon Lenze, Ph.D.
Washington Univeristy
42 participants (actual enrollment reported by the registry).
First Submitted
November 27, 2012
First Posted
December 6, 2012
Study Start
November 2012
Date type not reportedThis date has not been verified as actual or estimated.
A Randomized Controlled Trial of PCIT-ED for Preschool Depression
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Lenze SN, Potts MA, Rodgers J, Luby J. Lessons learned from a pilot randomized controlled trial of dyadic interpersonal psychotherapy for perinatal depression in a low-income population. J Affect Disord. 2020 Jun 15;271:286-292. doi: 10.1016/j.jad.2020.03.084. Epub 2020 Apr 15.
Primary Completion
January 31, 2017
Actual (reported)Study Completion
January 31, 2017
Actual (reported)Last Updated
January 11, 2022
Results First Posted
January 11, 2022
Record last verified: 2021-12
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Source: ClinicalTrials.gov.
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