Effects of Exercise Training in Patients With Mild Cognitive Impairment

NCT01724151 | Completed DMC

• 1 other identifier: 200812152R
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The proposes of this study are

1. 1.To understand the physical activities of patients with cognitive impairment in Taiwan and construct the validity and reliability of the physical activity questionnaire and actigram in this population.
2. 2.To understand the relation between brain structure (brain tractography and resting state functional MRI) and cognitive and physical functions of patients with cognitive impairment, the capability of activity and social engagement (including quality of life).
3. 3.To understand the efficacy of exercise on the brain structure (brain tractography and resting state functional MRI), cognitive and physical functions, the capability of activity and social engagement (including quality of life) of the patients with cognitive impairment.

Conditions

Mild Cognitive Impairment; Alzheimer's Disease

Outcome Measures

Primary Outcomes (1)

• Walking speed of participants

  Subjects walk through 10m walkway with steady comfortable pace. We record complete duration and calculate walking speed (m/sec)

  1 hour

Study Arms (3)

Healthy adults

Healthy adults, over 45 years old

Mild cognitive impairment

subjects with mild cognitive impairment

Alzheimer's disease

subjects with Alzheimer's disease

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

primary care clinic,community sample

You may qualify if:

• Above 45 years old and had independent walking ability
• The MCI is diagnosed basically on Petersen's criteria (Petersen, 2001), CDR score of 0.5 but normal ADL/IADL, and not demented
• Diagnosis of Alzheimer's disease based on NINCDS-ADRDA criteria for probable AD (McKhann, et al., 1984)

You may not qualify if:

• The subjects who had any neurological, musculoskeletal, cardio-pulmonary disorder which would cause gait disorder or cognitive dysfunction such as stroke, Parkinson disease, or arthritis were excluded

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, 100, Taiwan

Location

MeSH Terms

Conditions

Cognitive Dysfunction; Alzheimer Disease

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders; Dementia; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Tauopathies; Neurodegenerative Diseases

Study Officials

• Ming-Jang Chiu

  Neurology department, National Taiwan University Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 25, 2010
• First Posted: November 9, 2012
• Study Start: April 1, 2009
• Primary Completion: October 1, 2009
• Study Completion: April 1, 2012
• Last Updated: April 22, 2014

Record last verified: 2014-04

Locations

TW (1)