Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

NCT01720472 | Completed DMC

• 1 other identifier: Pro00036608
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 6

Brief Summary

The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in order to develop a diverse cohort with specific physical and cognitive performance data paired with biological samples.

Conditions

Aging; Physical Functioning; Cognitive Functioning; Fitness

Keywords

Aging; Healthy Aging; Physical Performance; Physical Functioning; Cognitive Functioning; Fitness; Physical Activity

Outcome Measures

Primary Outcomes (1)

• Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

  Factors associated with physical function and physical activity and change in physical activity and function over two-year follow-up.

  Upto 2 years or 24 months

Study Arms (1)

Community, Physical Performance

Genetic: Biomarker studies

Interventions

Biomarker studies GENETIC

Community, Physical Performance

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population will include 1,000 participants ages 30 and older living in Cabarrus County and/or the city of Kannapolis, or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina.

You may qualify if:

• A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina for 6 or more months of the year.
• Age 30 or older

You may not qualify if:

• Female that is currently pregnant
• Having had a heart attack, angina, congestive heart failure, or fluid in the lungs within the past 6 months
• Participant that requires consent by a legally authorized representative
• Participant that cannot walk 30ft without human assistance

Sponsors & Collaborators

• Duke University: lead

Study Sites (6)

Bethesda Health Center

Charlotte, North Carolina, 28262, United States

Location

McGill Family Medicine

Concord, North Carolina, 28025, United States

Location

Carolinas Medical Center NorthEast Medical Arts Building

Concord, North Carolina, 28205, United States

Location

Ada Jenkins Center

Davidson, North Carolina, 28036, United States

Location

Harrisburg Sleep Center

Harrisburg, North Carolina, 28075, United States

Location

Lake Norman Community Health Clinic

Huntersville, North Carolina, 28078, United States

Location

Related Publications (1)

• Parker D, Sloane R, Pieper CF, Hall KS, Kraus VB, Kraus WE, Huebner JL, Ilkayeva OR, Bain JR, Newby LK, Cohen HJ, Morey MC. Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):283-289. doi: 10.1093/gerona/gly121.

  PMID: 29985987 DERIVED

Related Links

• MURDOCK Study Physical Performance Cohort

Biospecimen

Retention: SAMPLES WITH DNA

Serum and plasma samples collected from MURDOCK Study enrollment visit and two year follow up Physical Performance visit.

MeSH Terms

Conditions

Motor Activity

Condition Hierarchy (Ancestors)

Behavior

Study Officials

• Miriam C Morey, Ph.D.

  Duke University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 31, 2012
• First Posted: November 2, 2012
• Study Start: May 1, 2012
• Primary Completion: August 28, 2018
• Study Completion: August 28, 2018
• Last Updated: January 31, 2019

Record last verified: 2019-01

Locations

US (6)