Inflammatory Response in Appendicitis

NCT01718171 | Completed

• 1 other identifier: HLS-0044-2012
• Study Type: observational
• Target: 183
• Locations: 1 country
• Sites: 1

Brief Summary

Although the presence of SIRS has been described in patients with appendicitis, its progressive response related and together with progression of symptomatology from the onset of symptoms to diagnostic has not been characterized. Continuation of the systemic inflammation in patients with injury and infectious processes may result in multiple organ dysfunction and ultimately failure. As with any acute inflammatory condition, the patients' systemic inflammatory response to appendicitis will progress and become more intense with the passing of time. The purpose of this study is to characterize the systemic inflammatory response to appendicitis from the beginning of symptoms to diagnostic in patients with appendicitis submitted to emergency surgery.

Conditions

Appendicitis

Keywords

Appendicitis; SIRS; C-reactive protein

Outcome Measures

Primary Outcomes (1)

• THE EXPECTED SYSTEMIC INFLAMMATORY RESPONSE TO APPENDICITIS

  Four groups of time intervals divided as follows: Group I: 0 - 24 hours Group II: 25 - 48 hours Group III: 49 - 72 hours Group IV: More than 73 hours

  0 to more than 72 hours

Secondary Outcomes (1)

• THE ANALYSIS OF C REACTIVE PROTEIN TO MEASURE THE SYSTEMIC INFLAMMATORY RESPONSE TO APPENDICITIS

  from 0 to more than 72 hours

Study Arms (1)

Group I, Group II, Group III, Group IV

Values and results of the Systemic Inflammatory Response and C-reactive protein to appendicitis

Eligibility Criteria

• Age: 15 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with appendicitis operated on and confirmed with biopsy

You may qualify if:

• Patients with appendicitis

You may not qualify if:

• Any patient with immunosuppressive or immunodeppressive known pathological conditions
• Any patient with a pathological report describing a normal appendix

Sponsors & Collaborators

• Cirujanos la Serena: lead

Study Sites (1)

Hospital de La Serena (La Serena Hospital)

La Serena, Coquimbo Region, 17000000, Chile

Location

MeSH Terms

Conditions

Appendicitis

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases

Study Officials

• Marcelo A Beltran, M.D.

  La Serena Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: DIGESTIVE SURGEON

Study Record Dates

• First Submitted: October 29, 2012
• First Posted: October 31, 2012
• Study Start: January 1, 2011
• Primary Completion: January 1, 2012
• Study Completion: July 1, 2012
• Last Updated: October 31, 2012

Record last verified: 2012-10

Locations

CL (1)