Diagnostic Performance of C Reactive Protein and Delta CRP in Acute Appendicitis

NCT02730585 | Completed

• 1 other identifier: 04/2016
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The diagnosis of acute appendicitis is difficult and despite important advances in medical sciences, detailed patient questioning and precise medical examination are the main keystones of the diagnosis of acute appendicitis and up to now, results still unsatisfactory.

Conditions

Appendicitis

Keywords

C-reactive protein

Outcome Measures

Primary Outcomes (1)

• Final diagnosis of acute appendicitis

  The final diagnosis of acute appendicitis was based, in operated patients, on the results of the histologic examination of the excised appendix and, in non operated patients, on the absence of acute appendicitis at the 2 weeks follow-up visit.

  15 days from patients inclusion

Study Arms (1)

Acute appendicitis

all patients admitted to our hospital with a clinically suspected acute appendicitis.

Biological: C-reactive protein measurement

Interventions

C-reactive protein measurement BIOLOGICAL

All patients included in this study underwent a blood sample analysis for C-reactive protein concentrations at admission and 3 hours later.

Acute appendicitis

Eligibility Criteria

• Age: 10 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients presenting to the Fattouma Bourguiba University hospital with an equivocal diagnosis of acute appendicitis. The clinical suspiscion of appendicitis was made based on anamnestic and physical examination findings.

You may qualify if:

• age \> 8 year old
• clinical suspicion of acute appendicitis including the presence of direct tenderness in the right lower quadrant, percussion and rebound tenderness, pyrexia, anorexia, nausea and vomiting.

You may not qualify if:

• patients receiving anti coagulants
• pregnant women
• patients using antibiotics during the study period.

Sponsors & Collaborators

• University of Monastir: lead

Study Sites (1)

Emergency department of university hospital Fattouma Bourguiba of Monastir

Monastir, 5000, Tunisia

Location

Related Publications (3)

• Hallan S, Asberg A. The accuracy of C-reactive protein in diagnosing acute appendicitis--a meta-analysis. Scand J Clin Lab Invest. 1997 Aug;57(5):373-80. doi: 10.3109/00365519709084584.

  PMID: 9279962 BACKGROUND

• Davies AH, Bernau F, Salisbury A, Souter RG. C-reactive protein in right iliac fossa pain. J R Coll Surg Edinb. 1991 Aug;36(4):242-4.

  PMID: 1941740 BACKGROUND

• Paajanen H, Mansikka A, Laato M, Ristamaki R, Pulkki K, Kostiainen S. Novel serum inflammatory markers in acute appendicitis. Scand J Clin Lab Invest. 2002;62(8):579-84. doi: 10.1080/003655102764654312.

  PMID: 12564616 BACKGROUND

MeSH Terms

Conditions

Appendicitis

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases

Study Officials

• Nouira Semir, Professor

  University Hospital of Monastir

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 1, 2016
• First Posted: April 6, 2016
• Study Start: January 1, 2010
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2013
• Last Updated: September 1, 2016

Record last verified: 2016-08

Locations

TU (1)