The Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) for Malaria Prevention
Cluster Randomised Trial to Compare Effectiveness of the Combined Use of Indoor Residual Spraying (IRS) and Long-lasting Insecticidal Nets (LLINs) to LLINs Alone for Malaria Prevention in Muleba District, Kagera Region, Tanzania
1 other identifier
interventional
22,300
1 country
1
Brief Summary
The study is a cluster randomised trial to compare the effectiveness of indoor residual spraying (IRS) combined with the use of long lasting insecticidal nets (LLINs) with the effectiveness of LLINs alone for preventing malaria infection and morbidity. The primary outcome measure is prevalence of parasitaemia and anaemia in children aged 0.5-10 years, measured in cross sectional surveys. Secondary outcomes include relative population density for each mosquito vector species, malaria transmission as measured by entomological inoculation rates (EIR) by mosquito vector species, monitoring of resistance markers including kdr, and user acceptability of LLINs compared with IRS. Findings from this study are expected to inform decision making so that resource utilization can be optimised.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_4
Started Jan 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2011
CompletedFirst Submitted
Initial submission to the registry
September 21, 2012
CompletedFirst Posted
Study publicly available on registry
October 2, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedOctober 3, 2012
October 1, 2012
1.8 years
September 21, 2012
October 2, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Prevalence of malarial infection in children 6 months to 10 years
9 months post randomisation
Secondary Outcomes (2)
Moderate to severe anaemia in children under 5 years
9 months post randomisation
Post-spraying prevalence of infection with malarial parasites in children 6 months to 10 years
6 months post randomisation
Other Outcomes (3)
Entomological Innoculation Rate
Malaria season post randomisation(Average value during 6 months after randomisation)
Relative abundance of adult Anopheles mosquitoes by species
Malaria season post randomisation (Average value during 6 months after randomisation)
genotypic markers of insecticide resistance in malaria vector mosquitoes
Malaria season post randomisation (Average value during 6 months after randomisation)
Study Arms (2)
LLIN plus IRS
EXPERIMENTALLLIN by universal coverage campaign 2 rounds of indoor residual spraying with bendiocarb insecticide
LLIN only
ACTIVE COMPARATORLLIN by universal coverage campaign
Interventions
2 rounds of indoor residual spraying with bendiocarb insecticide, 4 months apart
Long lasting Insecticide treated mosquito net
Eligibility Criteria
You may qualify if:
- resident in selected cluster (village)
You may not qualify if:
- Not resident in selected cluster (village)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
PAMVERC office
Muleba, Kagera, Tanzania
Related Publications (4)
Kleinschmidt I, Schwabe C, Shiva M, Segura JL, Sima V, Mabunda SJ, Coleman M. Combining indoor residual spraying and insecticide-treated net interventions. Am J Trop Med Hyg. 2009 Sep;81(3):519-24.
PMID: 19706925BACKGROUNDWest PA, Protopopoff N, Rowland MW, Kirby MJ, Oxborough RM, Mosha FW, Malima R, Kleinschmidt I. Evaluation of a national universal coverage campaign of long-lasting insecticidal nets in a rural district in north-west Tanzania. Malar J. 2012 Aug 10;11:273. doi: 10.1186/1475-2875-11-273.
PMID: 22882836RESULTWest PA, Protopopoff N, Wright A, Kivaju Z, Tigererwa R, Mosha FW, Kisinza W, Rowland M, Kleinschmidt I. Enhanced protection against malaria by indoor residual spraying in addition to insecticide treated nets: is it dependent on transmission intensity or net usage? PLoS One. 2015 Mar 26;10(3):e0115661. doi: 10.1371/journal.pone.0115661. eCollection 2015.
PMID: 25811379DERIVEDWest PA, Protopopoff N, Wright A, Kivaju Z, Tigererwa R, Mosha FW, Kisinza W, Rowland M, Kleinschmidt I. Indoor residual spraying in combination with insecticide-treated nets compared to insecticide-treated nets alone for protection against malaria: a cluster randomised trial in Tanzania. PLoS Med. 2014 Apr 15;11(4):e1001630. doi: 10.1371/journal.pmed.1001630. eCollection 2014 Apr.
PMID: 24736370DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mark Rowland, PHD
London School of Hygiene and Tropical Medicine
- PRINCIPAL INVESTIGATOR
Immo Kleinschmidt, PHD
London School of Hygiene and Tropical Medicine
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
September 21, 2012
First Posted
October 2, 2012
Study Start
January 1, 2011
Primary Completion
November 1, 2012
Study Completion
December 1, 2012
Last Updated
October 3, 2012
Record last verified: 2012-10