NCT01696721

Brief Summary

In previous studies, Proton Beam Radiation Therapy (PBRT) has been found to show better results in treating patients with cancer, both because there is better control of where in the body the radiation is directed and because it is associated with less severe long term side effects. However, there is limited published data demonstrating these results. The goal of the Proton and Photon Consortium Registry (PPCR) is to enroll children treated with radiation in order to describe the population that currently receives radiation and better compare the short-term and long-term benefits of different types of radiotherapy. The data collected from this study will help facilitate research on radiation therapy and allow for collaborative research. The PPCR will collect demographic and clinical data that many centers that deliver radiation therapy already collect in routine operations.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
5,000

participants targeted

Target at P75+ for all trials

Timeline
31mo left

Started Jul 2012

Longer than P75 for all trials

Geographic Reach
3 countries

26 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress84%
Jul 2012Dec 2028

Study Start

First participant enrolled

July 1, 2012

Completed
3 months until next milestone

First Submitted

Initial submission to the registry

September 27, 2012

Completed
4 days until next milestone

First Posted

Study publicly available on registry

October 1, 2012

Completed
16.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2028

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2028

Last Updated

January 7, 2026

Status Verified

January 1, 2026

Enrollment Period

16.4 years

First QC Date

September 27, 2012

Last Update Submit

January 5, 2026

Conditions

Pediatric Patients Treated With Radiation Therapy

Keywords

Proton TherapyPediatricsRadiation OncologyPhoton Therapy

Outcome Measures

Primary Outcomes (1)

  • Establish Registry

    Establish a registry of pediatric patients treated with proton radiation therapy in the United States

    2 years

Secondary Outcomes (4)

  • Describe patterns of care

    2 years

  • Describe patterns of follow-up

    2 years

  • Describe acute and late effects

    2 years

  • Establish a cohort of photon-treated patients

    2 years

Study Arms (1)

Pediatric Patients Treated with Protons

Proton Radiation Therapy

Other: No intervention

Interventions

No interventionOTHER
Pediatric Patients Treated with Protons

Eligibility Criteria

AgeUp to 21 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Pediatric patients age \<22 treated with radiation therapy

Eligibility Criteria: 1. Patients treated with radiation therapy at one of the participating centers 2. Age \< 22 at time of treatment start. 3. Patients may be enrolled regardless of previous local or systemic treatments received prior to enrollment in the PPCR. 4. Patients may be enrolled regardless of other current local or systemic treatments or disease extent. 5. Patients may be enrolled on the PPCR concurrently with another study or clinical trial.

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Study Sites (26)

Stanford University

Palo Alto, California, 94304, United States

RECRUITING

California Protons Cancer Therapy Center

San Diego, California, 92121, United States

RECRUITING

University of California San Francisco

San Francisco, California, 94143, United States

RECRUITING

University of Florida Health Proton Therapy Institute

Jacksonville, Florida, 32206, United States

RECRUITING

Emory University

Atlanta, Georgia, 30308, United States

RECRUITING

Northwestern Medicine Chicago Proton Center

Warrenville, Illinois, 60555, United States

RECRUITING

Maryland Proton Treatment Center

Baltimore, Maryland, 21201, United States

RECRUITING

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

RECRUITING

Mayo Clinic

Rochester, Minnesota, 55905, United States

RECRUITING

Washington University

St Louis, Missouri, 63110, United States

RECRUITING

ProCure Proton Therapy Center- New Jersey

Somerset, New Jersey, 08873, United States

RECRUITING

New York Proton Center

New York, New York, 10035, United States

RECRUITING

State University of New York Upstate Medical Center

Syracuse, New York, 13210, United States

RECRUITING

University of North Carolina

Chapel Hill, North Carolina, 27514, United States

RECRUITING

The Ohio State University

Columbus, Ohio, 43210, United States

RECRUITING

Cincinnati Children's Proton Therapy Center

Liberty Township, Ohio, 45044, United States

RECRUITING

Oklahoma Proton Center

Oklahoma City, Oklahoma, 73142, United States

RECRUITING

ProCure Proton Therapy Center- Oklahoma

Oklahoma City, Oklahoma, 73142, United States

RECRUITING

University of Pennsylvania - Roberts Proton Therapy Center

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

Provision Center for Proton Therapy

Knoxville, Tennessee, 37909, United States

ACTIVE NOT RECRUITING

MD Anderson Cancer Center

Houston, Texas, 77030, United States

RECRUITING

Texas Center for Proton Therapy

Irving, Texas, 75063, United States

RECRUITING

University of Utah

Salt Lake City, Utah, 84112, United States

RECRUITING

University of Washington- Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States

RECRUITING

Royal Adelaide Hospital

Adelaide, South Australia, 5000, Australia

RECRUITING

University Health Network - Princess Margaret Hospital

Toronto, Ontario, M5G 2C1, Canada

RECRUITING

Related Publications (1)

  • Krisch JM, Ermoian RP, Indelicato DJ, Lee JY, Perentesis JP, Perkins SM, Laack NN 2nd, Chang JH, MacEwan IJ, Wolden SL, Wang D, Yock TI, Aridgides PD. Outcomes following radiation therapy for embryonal tumor with multilayered rosettes (ETMR): results from the Pediatric Proton/Photon Consortium Registry (PPCR). J Neurooncol. 2025 Sep;174(2):369-380. doi: 10.1007/s11060-025-05065-2. Epub 2025 May 13.

    PMID: 40358803DERIVED

Study Officials

  • Torunn I Yock, MD

    Massachusetts General Hospital

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Torunn I Yock, MD

CONTACT

6177266876tyock@partners.org

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

September 27, 2012

First Posted

October 1, 2012

Study Start

July 1, 2012

Primary Completion (Estimated)

December 1, 2028

Study Completion (Estimated)

December 1, 2028

Last Updated

January 7, 2026

Record last verified: 2026-01

Locations

US(24)AU(1)CA(1)