Mindfulness-based Stress Reduction and Cognitive Function in Stress and Aging
1 other identifier
interventional
103
1 country
2
Brief Summary
The investigators are developing and then testing whether Mindfulness-Based Stress Reduction, a group-based instruction for increasing mindfulness, reduces anxiety and depressive symptoms and improves cognitive functioning in older adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_1
Started Oct 2011
Typical duration for phase_1
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2011
CompletedFirst Submitted
Initial submission to the registry
March 29, 2012
CompletedFirst Posted
Study publicly available on registry
September 26, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2014
CompletedJuly 23, 2014
July 1, 2014
2.7 years
March 29, 2012
July 21, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
cognitive functioning
neuropsychological battery examining memory, executive functioning, and attention
approximately 2 months of study intervention
Secondary Outcomes (3)
mind-wandering
2 months of intervention
mindfulness
2 months of intervention
anxiety and depressive symptoms
2 months of intervention
Study Arms (2)
Mindfulness Based Stress Reduction
EXPERIMENTALAll participants in this arm receive Mindfulness Based Stress Reduction (MBSR).
control
ACTIVE COMPARATORAll participants in this arm receive an attention control
Interventions
Eligibility Criteria
You may qualify if:
- aged 65+
- current depressive and/or anxiety symptoms
- current depressive and/or anxiety disorder
- able to participate in behavioral study
You may not qualify if:
- unable to participate in study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
University of California San Diego
San Diego, California, 92122, United States
Washington University School of Medicine
St Louis, Missouri, 63110, United States
Related Publications (3)
Kornfield SL, Nicol GE, Lenze EJ, Yingling M, Loebach Wetherell J. Mindfulness-Based Stress Reduction in Older Individuals: Who Benefits the Most? Adv Mind Body Med. 2022 Winter;36(1):4-12.
PMID: 35476747DERIVEDHaddad R, Lenze EJ, Nicol G, Miller JP, Yingling M, Wetherell JL. Does patient expectancy account for the cognitive and clinical benefits of mindfulness training in older adults? Int J Geriatr Psychiatry. 2020 Jun;35(6):626-632. doi: 10.1002/gps.5279. Epub 2020 Mar 20.
PMID: 32017250DERIVEDWetherell JL, Hershey T, Hickman S, Tate SR, Dixon D, Bower ES, Lenze EJ. Mindfulness-Based Stress Reduction for Older Adults With Stress Disorders and Neurocognitive Difficulties: A Randomized Controlled Trial. J Clin Psychiatry. 2017 Jul;78(7):e734-e743. doi: 10.4088/JCP.16m10947.
PMID: 28686822DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Eric Lenze, MD
Washington University School of Medicine
- PRINCIPAL INVESTIGATOR
Julie Wetherell, PhD
University of California, San Diego
Study Design
- Study Type
- interventional
- Phase
- phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor of Psychiatry
Study Record Dates
First Submitted
March 29, 2012
First Posted
September 26, 2012
Study Start
October 1, 2011
Primary Completion
June 1, 2014
Study Completion
June 1, 2014
Last Updated
July 23, 2014
Record last verified: 2014-07