NCT01686113

Brief Summary

This study will examine whether or not short, daily exposures change a person's ability to detect free fatty acids in a solution by its taste. Repeated exposure should improve a person's ability to detect free fatty acids.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
100

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started May 2012

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2012

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

September 12, 2012

Completed
5 days until next milestone

First Posted

Study publicly available on registry

September 17, 2012

Completed
1.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2014

Completed
Last Updated

November 21, 2014

Status Verified

November 1, 2014

Enrollment Period

2 years

First QC Date

September 12, 2012

Last Update Submit

November 20, 2014

Conditions

Hypogeusia

Keywords

TasteFat TasteThreshold Testing

Outcome Measures

Primary Outcomes (1)

  • NEFA detection threshold

    10 days

Secondary Outcomes (3)

  • Hunger

    2 days

  • BMI

    1 day

  • Taste descriptor

    10 days

Study Arms (2)

NEFA

EXPERIMENTAL

Participants swish and spit 5 mL of an oleic acid solution everyday for 10 days.

Other: NEFA

Control

ACTIVE COMPARATOR

Participants swish and spit 5 mL of sucrose solution everyday for 10 days.

Other: Sucrose

Interventions

NEFAOTHER
Also known as: Oleic acid
NEFA
SucroseOTHER
Control

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • good health
  • available for multiple testing visits

You may not qualify if:

  • have participated in a fat taste study in the past 6 months

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Purdue University

West Lafayette, Indiana, 47907, United States

Location

MeSH Terms

Conditions

Ageusia

Interventions

Fatty Acids, NonesterifiedOleic AcidSucrose

Condition Hierarchy (Ancestors)

Taste DisordersSensation DisordersNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Fatty AcidsLipidsOleic AcidsFatty Acids, MonounsaturatedFatty Acids, UnsaturatedDisaccharidesOligosaccharidesPolysaccharidesCarbohydratesSugars

Study Officials

  • Richard D Mattes, PhD

    Purdue University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Distinguished Prof Foods and Nutrition

Study Record Dates

First Submitted

September 12, 2012

First Posted

September 17, 2012

Study Start

May 1, 2012

Primary Completion

May 1, 2014

Study Completion

May 1, 2014

Last Updated

November 21, 2014

Record last verified: 2014-11

Locations

US(1)