Nutrient Timing Following Resistance Exercise

NCT01674049 | Completed DMC

• 1 other identifier: 081025
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the proposed study is to examine the timing of post-exercise feeding on 15 hours post-exercise glycemic control and metabolic flexibility and in overweight and obese young men with a family history of type 2 diabetes. Aim 1 - To determine the temporal effects of post-exercise feeding (i.e., immediate post-exercise vs. 3 hours post-exercise) on glycemic control, peripheral insulin sensitivity, and metabolic flexibility (as evaluated by sleep RQ) in this same group of participants. We hypothesize that a 3 hour delay in nutrient ingestion will promote significantly greater improvements in glucose tolerance, metabolic flexibility, and peripheral insulin sensitivity both immediately and several hours post-ingestion.

Conditions

Type 2 Diabetes

Keywords

nutrition; nutrient; timing; diabetes; family history; dairy

Outcome Measures

Primary Outcomes (1)

• Blood Glucose

  Continuous Glucose Monitoring was used for about 48 hours, from the time the participants entered the chamber on the control day through their release two days later

  48 hours

Secondary Outcomes (1)

• Serum insulin

  2 hours post supplement ingestion

Study Arms (2)

Exercise and Immediate Nutrition

EXPERIMENTAL

40 min of circuit-style resistance exercise and 600g low-fat chocolate milk immediately after the exercise bout

Dietary Supplement: Immediate Nutrition; Other: Resistance Exercise

Exercise and Nutrition 3 hours Post-Bout

ACTIVE COMPARATOR

40 min of circuit-style resistance exercise and 600g low-fat chocolate milk three hours after the exercise bout

Dietary Supplement: Nutrition 3 hours Post-Bout; Other: Resistance Exercise

Interventions

Immediate Nutrition DIETARY_SUPPLEMENT

Nutritional supplement consumed either immediately following a 40min resistance exercise bout

Exercise and Immediate Nutrition

Nutrition 3 hours Post-Bout DIETARY_SUPPLEMENT

Nutritional supplement (600g low-fat chocolate milk) consumed three hours after the exercise bout

Exercise and Nutrition 3 hours Post-Bout

Resistance Exercise OTHER

A single 40 minute circuit-style bout of resistance exercise

Exercise and Immediate Nutrition; Exercise and Nutrition 3 hours Post-Bout

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• BMI= 18-30
• Report at least one first degree relative with family history of type 2 diabetes - Healthy with no self-report of diagnosis of chronic disease

You may not qualify if:

• Self-report prior diagnosis of cardiovascular disease, pulmonary disease, adult asthma, dyspnea on exertion, current bronchitis, pneumonia, or tuberculosis, vascular disease, any intercurrent infection, hematologic/oncologic, any metastatic malignancy, anemia (hematocrit \<35), thrombocytopenia, neutropenia, hematologic malignancy, bleeding dyscrasias, neurologic disorder, endocrine disorder, chronic renal diseases
• Any illegal drug use
• Coumadin, heparin, beta blocker, growth hormone supplementation, or illegal drug use
• Skeletal-muscular injury in the last 6 months (including severe sprains, broken bones, and tendon or ligament injuries)
• Alcohol use in excess of 2 drinks per day
• Smokers

Sponsors & Collaborators

• George Washington University: lead
• United States Department of Agriculture (USDA): collaborator

Study Sites (1)

The George Washington University

Washington D.C., District of Columbia, 20052, United States

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Diabetes Mellitus

Interventions

Nutritional Status; Resistance Training

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena; Health Status; Demography; Population Characteristics; Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Jean L Gutierrez, PhD

  The George Washington University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 24, 2012
• First Posted: August 28, 2012
• Study Start: October 1, 2010
• Primary Completion: May 1, 2011
• Study Completion: May 1, 2011
• Last Updated: August 29, 2012

Record last verified: 2012-08

Locations

US (1)