NCT01659034

Brief Summary

The purpose of this study is to evaluate safety of reduction of thienopyridine treatment period to 3 months after implantation of Cobalt-Chromium everolimus-eluting Stents.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,525

participants targeted

Target at P75+ for phase_4 coronary-artery-disease

Timeline
Completed

Started Sep 2012

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 30, 2012

Completed
8 days until next milestone

First Posted

Study publicly available on registry

August 7, 2012

Completed
25 days until next milestone

Study Start

First participant enrolled

September 1, 2012

Completed
2.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2014

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2014

Completed
Last Updated

December 10, 2015

Status Verified

December 1, 2015

Enrollment Period

2.1 years

First QC Date

July 30, 2012

Last Update Submit

December 9, 2015

Conditions

Keywords

Anti-platelet therapy

Outcome Measures

Primary Outcomes (1)

  • Major cardiovascular and bleeding events

    Composite of cardiovascular death, myocardial infarction, stroke (ischemic and hemorrhagic), stent thrombosis (definite stent thrombosis not resulting in myocardial infarction), and major bleeding (TIMI Major/Minor) Cardiovascular death, myocardial infarction and stent thrombosis are defined according to the definition in the Academic Research Consortium (ARC). Stroke is defined as ischemic or hemorrhagic stroke with symptoms lasting \> 24 hour. Major bleeding is defined according to the definition in the Thrombosis in Myocardial Infarction (TIMI).

    1-year

Secondary Outcomes (18)

  • Cardiovascular death/MI/stroke/definite ST

    1-year

  • Major bleeding (TIMI Major/Minor)

    1-year

  • Death/MI

    1-year

  • All-cause death

    1-year

  • Cardiovascular death/MI

    1-year

  • +13 more secondary outcomes

Study Arms (1)

Thienopyridine

EXPERIMENTAL

Thienopyridine treatment for 3 months after implantation of everolimus-eluting Stents

Drug: Thienopyridine for 3 months

Interventions

Thienopyridine

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Patients who received PCI using everolimus-eluting cobalt-chromium stents

You may not qualify if:

  • Patients who had been implanted drug-eluting stents other than everolimus-eluting cobalt-chromium stents

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Cardiovascular Medicine, Kyoto University Hospital

Kyoto, Kyoto, 606-8507, Japan

Location

MeSH Terms

Conditions

Coronary Artery Disease

Interventions

thienopyridine

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

  • Takeshi Kimura, MD, PhD

    Professor of Medicine, Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
phase 4
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
Professor of Medicine

Study Record Dates

First Submitted

July 30, 2012

First Posted

August 7, 2012

Study Start

September 1, 2012

Primary Completion

October 1, 2014

Study Completion

December 1, 2014

Last Updated

December 10, 2015

Record last verified: 2015-12

Locations