Modulation of Cognitive Control by Transcranial Direct Current Stimulation
1 other identifier
interventional
44
1 country
1
Brief Summary
Insufficient cognitive control over emotional distracters is characteristic for major depressive disorder (MDD). Hypoactivation of the dorsolateral prefrontal cortex (dlPFC) is associated with this deficit. In this study the investigators assess the effect of an enhancement of dlPFC activity in MDD patients by anodal transcranial direct current stimulation (tDCS) on cognitive control. In a double-blinded, balanced randomized, sham-controlled crossover trial the investigators determine the effect of a single-session tDCS to the left dlPFC on cognitive control in MDD patients and healthy controls. To assess the cognitive control the investigators use a delayed response working memory (DWM) task with pictures of varying valence presented during the delay period.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jul 2011
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2011
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2012
CompletedFirst Submitted
Initial submission to the registry
July 23, 2012
CompletedFirst Posted
Study publicly available on registry
July 30, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2012
CompletedDecember 31, 2013
December 1, 2013
11 months
July 23, 2012
December 29, 2013
Conditions
Outcome Measures
Primary Outcomes (1)
Correctness of response
The primary outcome measure is obtained during the intervention (20min tDCS or sham stimulation).
Secondary Outcomes (1)
Reaction time
The secondary outcome measure is obtained during the intervention (20min tDCS or sham stimulation).
Study Arms (2)
Anodal transcranial direct current stimulation
EXPERIMENTALAnodal transcranial direct current stimulation (tDCS) 20min, 1mA, F3 (EEG 10/20), reference right M. deltoideus
Sham transcranial direct current stimulation
SHAM COMPARATORSham transcranial direct current stimulation (tDCS) 40s, 1mA, F3 (EEG 10/20), reference right M. deltoideus
Interventions
Eligibility Criteria
You may qualify if:
- age \> 18
- informed consent
- in the patients group: Major depressive disorder, no antidepressant medication or stability over 1 week
You may not qualify if:
- seizures
- cardiac pacemaker
- deep brain stimulation
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Universitiy Hospital Tübingen
Tübingen, Germany
Related Publications (1)
Wolkenstein L, Plewnia C. Amelioration of cognitive control in depression by transcranial direct current stimulation. Biol Psychiatry. 2013 Apr 1;73(7):646-51. doi: 10.1016/j.biopsych.2012.10.010. Epub 2012 Dec 6.
PMID: 23219367DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professer
Study Record Dates
First Submitted
July 23, 2012
First Posted
July 30, 2012
Study Start
July 1, 2011
Primary Completion
June 1, 2012
Study Completion
December 1, 2012
Last Updated
December 31, 2013
Record last verified: 2013-12