The Head and Neck Tumor Biobank

NCT01644786 | Completed

• 1 other identifier: 12-4-004
• Study Type: observational
• Target: 419
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of the biobank is to enable future genomic based research on this Head and Neck Cancer patient population. The investigators will try to identify tumor factors that will predict cancer-related outcome in order to improve the outcome prediction after treatment in a patient-individualized manner.

Conditions

Head and Neck Squamous Cell Carcinoma

Keywords

head and neck; HNSCC; orophaynx; hypopharynx; larynx; nasopharynx; oral cavity; prospective study; predictive models for HNSCC; genomic analyses; outcome prediction

Outcome Measures

Primary Outcomes (1)

• Main Study Outcome

  Locoregional control and/or survival

  from enrollment to follow-up at 5 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All new patients with (suspected) mucosal HNSCC who are scheduled for diagnostic panendoscopy

You may qualify if:

• Patient with (suspected) mucosal HNSCC
• Tumor site: oropharynx, hypopharynx, larynx, nasopharynx, or oral cavity
• Scheduled for panendoscopy under general anesthesia
• Tumor size that permits harvesting of multiple biopsies, without risk of functional damage
• No previous treatment, except previous biopsy
• Age \>= 18 years

You may not qualify if:

• Small primary tumors, e.g. vocal cord tumors, that are too small to obtain multiple biopsies because of the associated risk of functionale damage
• Patients not undergoing panendoscopy during routine clinical work-up, e.g. because of examination under general anaesthesia already performed elsewhere, before referral to azM.

Sponsors & Collaborators

• Maastricht Radiation Oncology: lead

Study Sites (1)

Maastro

Maastricht, 6229, Netherlands

Location

Biospecimen

Retention: SAMPLES WITH DNA

mucosal HNSCC oropharynx, hypopharynx, larynx, nasopharynx, oral cavity

MeSH Terms

Conditions

Squamous Cell Carcinoma of Head and Neck; Laryngeal Diseases

Condition Hierarchy (Ancestors)

Carcinoma, Squamous Cell; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Head and Neck Neoplasms; Neoplasms by Site; Respiratory Tract Diseases; Otorhinolaryngologic Diseases

Study Officials

• Bernd Kremer, MD, PhD

  Maastricht University Medical Center

  PRINCIPAL INVESTIGATOR

• Bernd Lethaus, MD, PhD

  Maastricht University Medical Center

  PRINCIPAL INVESTIGATOR

• Ernst-Jan Speel, MD, PhD

  Maastricht University Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 17, 2012
• First Posted: July 19, 2012
• Study Start: August 1, 2012
• Primary Completion: August 1, 2023
• Study Completion: August 1, 2025
• Last Updated: October 2, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

NL (1)