Executive Function in Preterm Born Children: An Integrative Approach From Genetics to Brain Function

NCT01615523 | Unknown

• 1 other identifier: EF_MRI_EEG
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Hd-EEG and MRI measures are used to study the maturation of functional networks in order to identify the neural circuits underlying executive and memory processes in children born preterm. It will be determined whether children born preterm with executive function deficits will have an abnormal connectivity between basal ganglia and cortex due to WM injury. Moreover, the development of hd-EEG activity during sleep (coherence and travelling waves) and brain maturation of children and adolescents born preterm will be compared with the respective measures in healthy controls. This is of eminent importance as it helps to understand the nature of executive function and hence, it may help to develop neuroprotective strategies to prevent executive function deficits in these infants.

Conditions

Preterm Infants

Keywords

Executive functions

Study Arms (2)

Children/adolescents born preterm

Other: MRI, EEG and cognitive testing

Control children and adolescents

Other: MRI, EEG and cognitive testing

Interventions

MRI, EEG and cognitive testing OTHER

Sleep EEG and one MRI, executive function testing using Strrop test, BRIEF questionnaire and CantabEclipse

Children/adolescents born preterm; Control children and adolescents

Eligibility Criteria

• Age: 10 Years - 16 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Children and adolescents born preterm with their peers as controls

You may qualify if:

• Schoolchildren between 10 and 12 or 14 and 16 (born between 1996 and 1998 or between 2000 and 2002)
• Preterm group: born \<32 weeks of gestation
• Control group: siblings or friends of preterm group in one of the two age groups

You may not qualify if:

• Preterm Group: MDI \< 85 at 5 years of age; cerebral palsy
• Control Group: born \<37 weeks of gestation

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital Zurich, Division of Neonatology

Zurich, Canton of Zurich, 8091, Switzerland

Location

MeSH Terms

Interventions

Magnetic Resonance Spectroscopy; Neuropsychological Tests

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques; Psychological Tests; Behavioral Disciplines and Activities

Study Officials

• Cornelia F Hagmann, MD

  University Hospital Zurich, Division of Neonatology

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Cornelia Franziska Hagmann, MD

CONTACT

cornelia.hagmann@usz.ch

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 6, 2012
• First Posted: June 8, 2012
• Study Start: September 1, 2012
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: June 8, 2012

Record last verified: 2012-06

Locations

CH (1)