A Dose Escalation Study of OMP-54F28 in Subjects With Solid Tumors

NCT01608867 | Completed Phase 1

• 1 other identifier: 54F28-001
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 3

Brief Summary

This is an open-label Phase 1 dose escalation study of OMP-54F28 in subjects with a solid tumor for which there is no remaining standard curative therapy. Subjects will be assessed for safety, immunogenicity, pharmacokinetics, biomarkers, and efficacy. No formal interim analyses will be performed. Prior to enrollment, subjects will undergo screening to determine study eligibility. Upon enrollment, subjects will receive OMP-54F28 until disease progression. All subjects will receive Vitamin D3 daily and calcium carbonate twice daily from Day 0 through 30 days following the discontinuation of OMP-54F28. Dose escalation will be conducted to determine the maximum tolerated dose (MTD). Subjects will be dosed at 0.5, 1, 2.5, 5, and 10 mg/kg administered IV once every 3 weeks. No dose escalation or reduction will be allowed within a dose cohort. Intermediate doses (i.e., doses between the dose levels listed above) may also be tested upon agreement with the investigators and the study sponsor. In addition, alternate dosing schedule cohorts of OMP-54F28 (eg. every 4 week or every 6 week dosing) can be studied upon agreement with the investigators and the study sponsor. These alternative less frequent dosing schedules may be evaluated if emerging data suggest that once every 3 week dosing results in tolerability concerns. The first 2 subjects enrolled in a cohort will not be treated on the same day. The dose may be administered at any time during the day. Three subjects will be treated at each dose level if no dose-limiting toxicities (DLTs) are observed. If 1 of 3 subjects experiences a DLT, that dose level will be expanded to 6 subjects. If 2 or more subjects experience a DLT, no further subjects will be dosed at that level and 3 additional subjects will be added to the preceding dose cohort unless 6 subjects have already been treated at that dose level. Subjects will be assessed for DLTs from Days 0-28. Dose escalation for newly enrolled subjects, if appropriate, will occur after all subjects in a cohort have completed their Day 28 DLT assessment. Subjects who have a \>2-fold increase of their fasting β-CTX or a decline of \>3% in their bone mineral density (BMD) from screening or a T-score decline to \<-2.5 in the total femur or L1-L4 DEXA scan measurement will be started on zoledronic acid. Subjects with stable disease or a response at Day 56 will be allowed to continue to receive OMP-54F28 until disease progression. An additional 6 subjects will be enrolled in an expansion cohort at the highest dose level that results in \<2 of the 6 subjects experiencing a Grade 3 (not including a Grade 3 infusion reaction that resolves in 24 hours) or Grade 4 adverse event (DLT). Tumors of particular interest for inclusion in the expansion cohort include sarcomas, basal cell carcinoma, ovarian cancer, desmoid tumors and prostate cancer given the known importance of the Wnt pathway in these malignancies.

Conditions

Solid Tumors

Keywords

Phase 1; dose escalation; histologically confirmed; malignancy; metastatic

Outcome Measures

Primary Outcomes (1)

• • To determine the safety of OMP-54F28 in subjects with previously treated solid tumors

  Subjects will be assessed for dose limiting toxicities from Days 0-28. Adverse events will be reported through 30 days after the last dose.

Secondary Outcomes (3)

• To determine the pharmacokinetics of OMP-54F28 in subjects with previously treated solid tumors

  Baseline,end of infusion,0.5,1,3,6,24, and 72 hours post-infusion (1st infusion) 0.5, 1, 3, 6, 24, 72, and 168 hours (3rd infusion),before/end 2nd infusion,Days 7, 14, 28, and 35. After termination: Weekly for the first 4 weeks, then at Week 8 and 12

• To determine the immunogenicity of OMP-54F28 in subjects with previously treated solid tumors

  Subjects will be assessed during screening ,every 4 weeks while on study drug, at the time of treatment termination, then weekly for the first 4 weeks, then at Week 8 and 12 following discontinuation of study drug

• To assess the preliminary efficacy of OMP-54F28 in subjects with previously treated solid tumors

  Every 56 days until disease progression

Interventions

OMP-54F28 BIOLOGICAL

dose escalation of 0.5, 1, 2.5, 5, and 10 mg/kg administered IV once every 3 weeks

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects must meet all of the following criteria to be eligible for the study:
• Subjects must have a histologically confirmed malignancy that is metastatic or unresectable and must have received the standard therapies for their malignancy. In addition, subjects must have a tumor that is at least 1 cm in a single dimension and is radiographically apparent on CT or MRI.
• Subjects must have received their last chemotherapy, biologic, or investigational therapy at least 4 weeks prior to enrollment, 6 weeks if the last regimen included BCNU or mitomycin C.
• Age \>18 years
• ECOG performance status \<2 (see APPENDIX B)
• Estimated life expectancy of more than 3 months
• Subjects must have adequate organ and marrow function as defined below:
• Absolute neutrophil count \>1000/µL Hemoglobin \>9.0 g/dL Platelets \>100,000/µL Total bilirubin \<1.5 X institutional upper limit of normal (ULN) AST (SGOT) and ALT (SGPT) \<3 X institutional ULN (for subjects with hepatic metastases \<5 X institutional ULN) PT and PTT within 1.5 X institutional ULN Creatinine \<1.5 X institutional ULN OR Creatinine clearance \>60 mL/min/1.73 m2
• Women of childbearing potential must have had a prior hysterectomy or have a negative serum pregnancy test and be using adequate contraception prior to study entry and must agree to use adequate contraception from study entry through at least 6 months after discontinuation of study drug. Men must also agree to use adequate contraception (barrier method of birth control, abstinence) prior to study entry and from study entry through at least 6 months after discontinuation of study drug. Should a woman enrolled in the study or a female partner of a man enrolled in the study become pregnant or suspect she is pregnant while participating in this study or within 6 months after discontinuation of study, she should inform the Investigator immediately.
• Ability to understand and the willingness to sign a written informed consent document

You may not qualify if:

• Subjects who meet any of the following criteria will not be eligible for participation in the study:
• Subjects receiving any other investigational agents
• Subjects with brain metastases (subjects must have a CT scan or MRI of the head within 28 days prior to enrollment to rule out brain metastases), uncontrolled seizure disorder, or active neurologic disease
• History of a significant allergic reaction attributed to humanized or human monoclonal antibody therapy or Fc fusion protein
• Significant intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
• Pregnant women or nursing women
• Subjects with known HIV, Hepatitis B or Hepatitis C infection
• Known bleeding disorder or coagulopathy
• Subjects receiving heparin, warfarin, or other similar anticoagulants, except for subjects on low molecular weight heparin for DVT/PE prophylaxis. Note: Subjects may be receiving low-dose aspirin and/or non-steroidal anti-inflammatory agents.
• New York Heart Association Classification III, or IV (see APPENDIX D)
• Subjects with known clinically significant gastrointestinal disease including, but not limited to, inflammatory bowel disease.
• Subjects with osteopenia or osteoporosis on their screening DEXA bone density scan.
• Subjects with bone metastases that:
• have a prior history of a pathologic fracture,
• have a lytic lesion requiring an orthopedic intervention or

Sponsors & Collaborators

• OncoMed Pharmaceuticals, Inc.: lead
• Bayer: collaborator

Study Sites (3)

Pinnacle Oncology Hematology,

Scottsdale, Arizona, 85258, United States

Location

University of Colorado Hospital

Aurora, Colorado, 80045, United States

Location

University of Michigan Health System

Ann Arbor, Michigan, 48109, United States

Location

MeSH Terms

Conditions

Neoplasms; Neoplasm Metastasis

Interventions

OMP-54F28

Condition Hierarchy (Ancestors)

Neoplastic Processes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 29, 2012
• First Posted: May 31, 2012
• Study Start: June 1, 2012
• Primary Completion: August 1, 2016
• Study Completion: June 1, 2017
• Last Updated: August 11, 2020

Record last verified: 2020-08

Locations

US (3)