Key Highlights

Risk & Performance

Pipeline Risk Assessment

Pipeline Risk Assessment

Based on historical performance

High Risk

Score: 75/100

Failure Rate

17.9%

5 terminated/withdrawn out of 28 trials

Success Rate

82.1%

-4.4% vs industry average

Late-Stage Pipeline

0%

0 trials in Phase 3/4

Results Transparency

17%

4 of 23 completed trials have results

Key Signals

4 with results

Enrollment Performance

Analytics

Phase 1
26(92.9%)
Phase 2
2(7.1%)
28Total
Phase 1(26)
Phase 2(2)

Activity Timeline

Global Presence

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Clinical Trials (28)

Showing 20 of 28 trials
NCT01647828Phase 1Completed

A Phase 1b/2 Study of OMP-59R5 (Tarextumab) in Combination With Nab-Paclitaxel and Gemcitabine in Subjects With Previously Untreated Stage IV Pancreatic Cancer

Role: lead

NCT02289898Phase 2Completed

Study of Gemcitabine, Abraxane® Plus Placebo Versus Gemcitabine, Abraxane® Plus 1 or 2 Truncated Courses of Demcizumab in Subjects With 1st-Line Metastatic Pancreatic Ductal Adenocarcinoma

Role: lead

NCT00744562Phase 1Completed

A Phase 1 Dose Escalation Study of OMP-21M18 in Subjects With Solid Tumors

Role: lead

NCT01957007Phase 1Completed

A Study of Vantictumab (OMP-18R5) in Combination With Docetaxel in Patients With Previously Treated NSCLC

Role: lead

NCT01189942Phase 1Completed

A Study of FOLFIRI Plus OMP-21M18 as 1st or 2nd-line Treatment in Subjects With Metastatic Colorectal Cancer

Role: lead

NCT01703572Phase 1Completed

A Dose Escalation Study of OMP-52M51 in Subjects With Lymphoid Malignancies

Role: lead

NCT02050178Phase 1Completed

Dose Escalation Study of OMP-54F28 in Combination With Nab-Paclitaxel and Gemcitabine in Patients With Previously Untreated Stage IV Pancreatic Cancer

Role: lead

NCT02005315Phase 1Completed

A Study of Vantictumab (OMP-18R5) in Combination With Nab-Paclitaxel and Gemcitabine in Previously Untreated Stage IV Pancreatic Cancer

Role: lead

NCT01973309Phase 1Completed

A Study of Vantictumab (OMP-18R5) in Combination With Paclitaxel in Locally Recurrent or Metastatic Breast Cancer

Role: lead

NCT01345201Phase 1Completed

A Dose Escalation Study of OMP-18R5 in Subjects With Solid Tumors

Role: lead

NCT01189929Phase 1Completed

A Study of Gemcitabine and Demcizumab (OMP-21M18) With or Without Abraxane® as 1st-line Treatment in Subjects With Locally Advanced or Metastatic Pancreatic Cancer

Role: lead

NCT01952249Phase 1Terminated

A Study of Demcizumab Plus Paclitaxel in Subjects With Platinum Resistant Ovarian

Role: lead

NCT01189968Phase 1Completed

A Study of Carboplatin and Pemetrexed Plus Demcizumab (OMP-21M18) in Subjects With Non-Squamous Non-Small Cell Lung Cancer

Role: lead

NCT02259582Phase 2Completed

A Study of Carboplatin, Pemetrexed Plus Placebo vs Carboplatin, Pemetrexed Plus 1 or 2 Truncated Courses of Demcizumab in Subjects With Non-Squamous Non-Small Cell Lung Cancer

Role: lead

NCT01277146Phase 1Completed

A Dose Escalation Study of OMP-59R5 in Subjects With Solid Tumors

Role: lead

NCT01859741Phase 1Terminated

A Phase 1b/2 Study of OMP-59R5 (Tarextumab) in Combination With Etoposide and Platinum Therapy

Role: lead

NCT03030287Phase 1Completed

A Phase 1b Study of OMP-305B83 Plus Paclitaxel in Subjects With Ovarian, Peritoneal or Fallopian Tube Cancer

Role: lead

NCT02092363Phase 1Completed

Dose Escalation Study of OMP-54F28 in Combination With Paclitaxel and Carboplatin in Patients With Recurrent Platinum-Sensitive Ovarian Cancer

Role: lead

NCT02482441Phase 1Completed

A Phase 1a/b Dose Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of OMP-131R10

Role: lead

NCT01608867Phase 1Completed

A Dose Escalation Study of OMP-54F28 in Subjects With Solid Tumors

Role: lead