Evaluating In Vivo OCT Imaging for Periocular Basal Cell Carcinoma
An Investigation of the Correlation Between OCT and Histology in Defining the Margins of Periocular Basal Cell Carcinoma
1 other identifier
observational
N/A
1 country
1
Brief Summary
Optical coherence tomography (OCT) is an imaging technique which shows the internal structure of living tissue (in vivo). It is safe, quick and painless to perform, and does not damage the tissue in any way. Recent advances in the technology mean that it can now be used to take images of the internal structure of the skin. This is useful because certain conditions, such as skin cancers, alter this structure. At present a suspected skin cancer is identified by taking a sample (a biopsy) which is analysed under the microscope to confirm the diagnosis. The cancer is then excised including a margin of apparently healthy-looking skin around it to ensure that the entirety of the tumour is removed. The excised tumour is then analysed again under a microscope to confirm that it was indeed completely removed (histology), after which a further operation is required to repair the defect. The purpose of this study is to evaluate OCT imaging of a particular type of skin cancer called a basal cell carcinoma (BCC), and in particular BCCs affecting the skin around the eyes (periocular). The study will compare the ability of OCT to define the margin of the BCC with the current 'gold standard' of histology. OCT could potentially improve the investigators ability to define the margins of the tumour before surgery and become a guide for minimally invasive surgery. The preservation of healthy tissue represents a priority, particularly in the area of the skin surrounding the eye.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 19, 2012
CompletedFirst Posted
Study publicly available on registry
May 22, 2012
CompletedMay 22, 2012
May 1, 2012
May 19, 2012
May 21, 2012
Conditions
Keywords
Study Arms (1)
BCC
Adult of any age or gender with capacity to give informed consent who has a basal cell carinoma requiring surgical excision and involving the periocular skin
Interventions
Eligibility Criteria
Adults with periocular basal cell carcinoma
You may qualify if:
- Adults of any age or gender who have capacity to give informed consent, and who have periocular basal cell carcinoma requiring surgical excision
You may not qualify if:
- Children, vulnerable adults, inability to give informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Maidstone Hospital
Maidstone, Kent, ME16 9QQ, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Henry B Smith, FRCOphth
Maidstone & Tunbridge Wells NHS Trust
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Oculoplastics Fellow
Study Record Dates
First Submitted
May 19, 2012
First Posted
May 22, 2012
Last Updated
May 22, 2012
Record last verified: 2012-05