Successful Pregnancy and Delivery After AOA
1 other identifier
interventional
100
1 country
1
Brief Summary
Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started May 2007
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2011
CompletedFirst Submitted
Initial submission to the registry
May 9, 2012
CompletedFirst Posted
Study publicly available on registry
May 10, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2014
CompletedMay 9, 2025
January 1, 2014
4.3 years
May 9, 2012
May 6, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Fertilization rate
18 hours
Secondary Outcomes (3)
Embryo quality
3 Days
Pregnancy and Implantation rates
2 months
Assessment of Infant health care
birth and at 3, 6, 12, 24, 36, 60, and 72 months
Study Arms (2)
Conventional ICSI
ACTIVE COMPARATORThe couple showed complete fertilization failure after ICSI.
Convention ICSI
ACTIVE COMPARATORThe couple showed a low fertilization rates after ICSI.
Interventions
Oocytes were activated with calcium ionophore after ICSI
Oocytes were activated with strontium chloride after ICSI
Eligibility Criteria
You may qualify if:
- Fertilization rate was less than 30% after conventional ICSI.
- Fertilization rate was less than 50% after ICSI with calcium ionophore.
- Repeated complete fertilization failure or low fertilization rates following ICSI in previous cycles
You may not qualify if:
- Fertilization rate was more than 30% after conventional ICSI
- Fertilization rate was more than 50% after ICSI with calcium ionophore.
- Successful pregnancy and delivery after ICSI in previous cycles
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Maria Fertility Hospital
Seoul, 138-160, South Korea
Related Publications (1)
Kim JW, Yang SH, Yoon SH, Kim SD, Jung JH, Lim JH. Successful pregnancy and delivery after ICSI with artificial oocyte activation by calcium ionophore in in-vitro matured oocytes: a case report. Reprod Biomed Online. 2015 Apr;30(4):373-7. doi: 10.1016/j.rbmo.2014.11.014. Epub 2014 Dec 11.
PMID: 25592974DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Maria Fertility Hospital
Study Record Dates
First Submitted
May 9, 2012
First Posted
May 10, 2012
Study Start
May 1, 2007
Primary Completion
September 1, 2011
Study Completion
April 1, 2014
Last Updated
May 9, 2025
Record last verified: 2014-01