NCT01590706

Brief Summary

  • Although aging process appears to be generally characterized, investigators have been paid much attention to the specific target molecules, which leads to discover the clinical markers of the senescence. The present study is to investigate the clinical and biological profile of cognitive decline and functional cardiac senescence in healthy middle aged and elderly Korean volunteers.
  • This study was conducted as a cross-sectional, single-center, comparative clinical study.
  • Each volunteer was given informed consent for checking cognition and cardiac function. Blood and urine samples were collected to analyze genome, proteome, and metabolome to assess cognition and cardiac function of its muscle enzymes.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
116

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Nov 2011

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2011

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

May 1, 2012

Completed
2 days until next milestone

First Posted

Study publicly available on registry

May 3, 2012

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2012

Completed
5 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2013

Completed
Last Updated

April 2, 2014

Status Verified

April 1, 2014

Enrollment Period

11 months

First QC Date

May 1, 2012

Last Update Submit

April 1, 2014

Conditions

AgingMild Cognitive ImpairmentAngina Pectoris

Keywords

Genotype-Phenotype AssociationAgedMiddle AgedMild Cognitive ImpairmentHeart Rate ControlBiomarkers

Eligibility Criteria

Age45 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Healthy middle aged (45-64 age) and elderly (over 65 age) person

You may qualify if:

  • Healthy subjects \>= 45 and \<= 80 years of age
  • who understands the study procedures signs informed consent forms

You may not qualify if:

  • who \> 150 mmHg in systolic or \< 95 mmHg in diastolic blood pressure
  • who \> 110 mg/dl in fast glucose level
  • Smoking \> 20 cigarettes/day
  • Alcohol \> 3 units/day (1 unit = pure alcohol 10 milli Liter)
  • Caffeine \> 5 cups of coffee or tea/day

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Dunsan Oriental Hospital of Daejeon Univ.

Daejeon, 302122, South Korea

Location

Biospecimen

Retention: SAMPLES WITH DNA

Samples for single nucleotide polymorphism, and for cardiac enzyme level detection

MeSH Terms

Conditions

Cognitive DysfunctionAngina Pectoris

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental DisordersMyocardial IschemiaHeart DiseasesCardiovascular DiseasesVascular DiseasesChest PainPainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Miyoung Lee, PhD

    Korea Institute of Oriental Medicine

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Senior Investigator

Study Record Dates

First Submitted

May 1, 2012

First Posted

May 3, 2012

Study Start

November 1, 2011

Primary Completion

October 1, 2012

Study Completion

March 1, 2013

Last Updated

April 2, 2014

Record last verified: 2014-04

Locations

KR(1)