Cognitive Training to Promote Brain Health: Implementation and Engagement
1 other identifier
interventional
50
1 country
1
Brief Summary
Cognition encompasses memory, attention, language and other brain capacities that are necessary for good quality of life and independence. Age-related cognitive decline starts at the third decade of life and in some cases can start to impact daily functioning in the late forties. Dementia is the most devastating consequence associated with age-related cognitive decline. Recent studies indicate that improving cognition by means of intensive computerized brain training can mitigate some aspects of agerelated cognitive decline, and may even have a role in preventing or delaying dementia onset. Critically, the capacity of a given individual to improve their cognitive performance after training is fundamentally related to engagement with the exercises. Currently, little is known about how to apply intensive computerized cognitive training effectively in the health system, ensuring engagement and best progress. This project aims to tackle this challenge by developing, applying and testing personalized approaches to implement cognitive training in daily life of older adults that were recently evaluated at Memory Clinics and their care partners. The community readiness approach will be implemented using semi-structured interviews, conducted with subjects that may be interested in cognitive training, key informant, and key stakeholders. Using this information, the investigators will design an individualized training program and follow up its application in a feasibility trial. Twenty participants, recently evaluated at different Memory Clinics in Ireland, will be recruited, interviewed and invited to engage, over the ensuing 2 to 3 months, in computerized cognitive training. Subjects will be assessed after completion of the intervention for training adherence and individual gains on the computerized exercises. In order to gain insight about regional specificities of the approach the investigators will perform a parallel project using the same methodology in Brazil. This project is expected to inform the future implementation of cognitive training in public health policies for older adults.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_2
Started Jan 2018
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 12, 2018
CompletedStudy Start
First participant enrolled
January 12, 2018
CompletedFirst Posted
Study publicly available on registry
January 24, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2019
CompletedJanuary 26, 2018
January 1, 2018
2 years
January 12, 2018
January 24, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
Engagement
will be defined as a continuous variable (number of hours of training completed by the participant).
3 months
Secondary Outcomes (4)
Individual gains on the computerized exercises
3 months
Quantitative measure of motivation with the computerized training exercise
3 months
Qualitative motivation with the computerized training exercise
3 months
Training adherence (dichotomic variable)
3 months
Study Arms (1)
Cognitive training
EXPERIMENTALInterventions
Posit Science Inc. will supply the software for the computerized cognitive training through the platform BrainHQ, which is available on line. The training program consists of a set of computerized exercises designed to improve the speed and accuracy of sensory information processing while engaging neuromodulatory systems involved in attention and reward. The rationale is that, in order to understand and remember information, the brain must first generate precise and reliable neurological responses that represent the sensory stimuli. These exercises continuously adjust the difficulty level to user performance to maintain an approximately 85% rate of correct responses. Trials with correct responses are rewarded with points and animations. The goal is to increase the effectiveness with which these stimuli engage and drive plastic changes in brain systems. Engagement is monitored by electronic data upload following each training session.
Eligibility Criteria
You may qualify if:
- Being evaluated at a memory clinic in the last year, or be the care partner of a person evaluated at a memory clinic
- Adequate visual and auditory acuity to allow practice on the computerized training exercises
- Physical ability sufficient to allow performance of the computerized training exercises
- Provide signed and dated informed consent form.
- Willing to comply with all study procedures and be available for the duration of the study.
You may not qualify if:
- Any medical condition that precludes performing the computerized training exercises
- Advanced dementia.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Universidade Federal do Rio de Janeirolead
- University of Dublin, Trinity Collegecollaborator
- Global Brain Health Institute (GBHI)collaborator
Study Sites (1)
St James Hospital
Dublin, D8, Ireland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- NA
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
January 12, 2018
First Posted
January 24, 2018
Study Start
January 12, 2018
Primary Completion
December 31, 2019
Study Completion
December 31, 2019
Last Updated
January 26, 2018
Record last verified: 2018-01