Neuroimaging Markers of Alzheimer Disease: a Longitudinal Population Study

NCT01582919 | Completed

• 1 other identifier: CHUBX 2011/15
• Study Type: interventional
• Target: 304
• Locations: 1 country
• Sites: 1

Brief Summary

It is now acknowledged that Alzheimer's disease is characterized by a long period of pathophysiological change. Developing new strategies to achieve diagnoses as early as possible has become a major goal for therapies aimed at slowing the progression of this disease. While diagnoses currently rely principally on clinical neuropsychology, the typical diagnostic criteria of NINCDS-ADRDA are inapplicable in the early stage of the disease. The goal of our project is to identify very early imaging markers for Alzheimer's disease among patients with no report of cognitive difficulties. In order to achieve this goal, we propose a longitudinal study in an elderly population cohort.

Conditions

Dementia; Alzheimer Disease

Keywords

dementia; Alzheimer's Disease; diagnostic; biomarkers; neuroimaging; PET; MRI; mild cognitive impairment

Outcome Measures

Primary Outcomes (1)

• Measures of volume and diffusion parameters in the gray matter (hippocampus and cingular posterior cortex)

  Inclusion (Day 0)

Secondary Outcomes (1)

• Performance on neuropsychological and daily life cognitive tests

  Everyday up to Day 7 after inclusion

Study Arms (2)

Participant from AMI cohort

EXPERIMENTAL

Other: Neuroimaging

Participant from 3Ccohort

ACTIVE COMPARATOR

Other: Neuroimaging

Interventions

Neuroimaging OTHER

Participant from 3Ccohort; Participant from AMI cohort

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• At least 65 years old
• Be retired from agricultural profession
• live in rural area in Gironde (France)

You may not qualify if:

• Lefthanded
• having a dementia (MMSE \< 13)
• Having a vascular cerebral accident
• Parkinson disease
• Poor health condition does not allowing transport to neuroimaging service

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

Groupe Hospitalier Pellegrin - C.H.U. de Bordeaux

Bordeaux, 33000, France

Location

MeSH Terms

Conditions

Dementia; Alzheimer Disease; Disease; Cognitive Dysfunction

Interventions

Neuroimaging

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders; Tauopathies; Neurodegenerative Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cognition Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Neurological; Investigative Techniques

Study Officials

• Michèle ALLARD, Pr

  University Hospital, Bordeaux

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 20, 2012
• First Posted: April 23, 2012
• Study Start: September 1, 2012
• Primary Completion: June 1, 2015
• Study Completion: June 1, 2015
• Last Updated: April 4, 2017

Record last verified: 2017-03

Locations

FR (1)