Pulse Wave Analysis and Velocity in Patients With Chronic Renal Failure: a Cross-sectional Observational Study to Assess Association With Left Ventricular Hypertrophy, Uremic Toxins and Inflammation.

NCT01579032 | Completed

• 1 other identifier: ML2863
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 2

Brief Summary

The aims of the presented study are as follows:

1. 1.To evaluate the endothelial function and arterial stiffness in a large cohort of prevalent CKD patients by means of non-invasive applantion tonometry.
2. 2.To evaluate the association between the serum levels of the representatives of the various classes of uremic toxins and markers of endothelial function and arterial stiffness.
3. 3.To evaluate the association between markers of inflammation and oxidative stress and markers of endothelial function and arterial stiffness.
4. 4.To evaluate the association between echocardiographic parameters and markers of arterial stiffness

Conditions

Arterial Stiffness; CHRONIC RENAL FAILURE; Left Ventricular Hypertrophy

Keywords

CKD,

Study Arms (1)

CKD patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

CKD patients

You may qualify if:

• Age: 18-60
• Chronic kidney disease: according to the K-DOQI guidelines ( kidney damage ≥ three months, as defined by structural or functional abnormalities of the kidney, with or without decreased GFR, manifest by either: pathological abnormalities; or markers of kidney damage, including damage in the composition of blood or urine test, or abnormalities in imaging tests; GFR\< 60 ml/min/1.73m² for ≥ three months, with or without kidney damage)
• Written informed consent

You may not qualify if:

• major illnesses( life expectancy of \< 1 year)
• history of atrial fibrillation
• history of myocardial infarction, unstable angina, congestive heart failure, peripheral vascular diasease ,cerebrovascular disease, diabetes
• (nonechogenic)

Sponsors & Collaborators

• Universitaire Ziekenhuizen KU Leuven: lead

Study Sites (2)

University Hospitals

Leuven, 3000, Belgium

Location

UZ Leuven

Leuven, 3000, Belgium

Location

MeSH Terms

Conditions

Kidney Failure, Chronic; Hypertrophy, Left Ventricular

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cardiomegaly; Heart Diseases; Cardiovascular Diseases; Hypertrophy; Pathological Conditions, Anatomical

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 13, 2012
• First Posted: April 17, 2012
• Study Start: January 1, 2004
• Primary Completion: January 1, 2012
• Study Completion: January 1, 2012
• Last Updated: October 17, 2018

Record last verified: 2018-10

Locations

BE (2)