The Effect of Nocturnal Haemodialysis on Arterial Stiffness

NCT00641875 | Completed

• 1 other identifier: 2004.050
• Study Type: observational
• Target: 30
• Locations: 0 countries
• Sites: N/A

Brief Summary

Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.

Conditions

End Stage Renal Disease; Arterial Stiffness

Keywords

arterial stiffness; artery; aortic pulse wave velocity; pulse wave analysis; augmentation index; end stage renal disease; nocturnal hemodialysis; extended hours of hemodialysis; cardiovascular; hemodialysis

Outcome Measures

Primary Outcomes (1)

• To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis.

  12 months

Secondary Outcomes (1)

• To examine the relationship between arterial stiffness and clinical and biochemical parameters

  12 months

Interventions

Nocturnal Hemodialysis PROCEDURE

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All participants are adult patients who are receiving maintenance dialysis at the North West Dialysis Service. Consecutive patients enrolled in the Nocturnal Haemodialysis program are invited to participate in the study

You may qualify if:

• adult dialysis patients
• able to perform home nocturnal haemodialysis

You may not qualify if:

• age \< 18 and \> 80 years
• any patient who is anticipating a live renal transplantation in forthcoming 12 months

Sponsors & Collaborators

• Melbourne Health: lead

MeSH Terms

Conditions

Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Michael Lian, FRACP, MBBS

  Department of Nephrology, Melbourne Health

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 17, 2008
• First Posted: March 24, 2008
• Study Start: December 1, 2005
• Primary Completion: February 1, 2008
• Study Completion: February 1, 2008
• Last Updated: April 27, 2015

Record last verified: 2015-04