Arterial Stiffness and Calcifications in Incident Renal Transplant Recipients
ASCIT
1 other identifier
observational
304
1 country
1
Brief Summary
The purpose of this study is to determine the:
- Natural history of calcification posttransplantation
- Natural history of BMC following renal transplantation
- Reverse correlation between calcification score and aortic calcifications following renal transplantation
- Correlation of IMT, BMC, PWV and biochemical variables
- Correlation of IMT, BMC, PWV, biochemical variables and outcome
- Predictors of CV disease after transplantation
- Predictors of IMT progression, BMC loss and PWV progression after renal transplantation
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Oct 2006
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2006
CompletedFirst Submitted
Initial submission to the registry
October 18, 2007
CompletedFirst Posted
Study publicly available on registry
October 19, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2013
CompletedOctober 16, 2018
October 1, 2011
7 years
October 18, 2007
October 13, 2018
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
cardiovascular outcome
5 years
Study Arms (1)
A
incident renal transplant patients
Interventions
Eligibility Criteria
incident renal transplant recipients
You may qualify if:
- Incident renal transplant patients or combined renal/pancreas transplant patients
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
UZ Gasthuisberg
Leuven, 3000, Belgium
Related Publications (3)
Jorgensen HS, Claes K, Smout D, Naesens M, Kuypers D, D'Haese P, Cavalier E, Evenepoel P. Associations of Changes in Bone Turnover Markers with Change in Bone Mineral Density in Kidney Transplant Patients. Clin J Am Soc Nephrol. 2024 Apr 1;19(4):483-493. doi: 10.2215/CJN.0000000000000368. Epub 2023 Nov 29.
PMID: 38030558DERIVEDEvenepoel P, Claes K, Viaene L, Bammens B, Meijers B, Naesens M, Sprangers B, Kuypers D. Decreased Circulating Sclerostin Levels in Renal Transplant Recipients With Persistent Hyperparathyroidism. Transplantation. 2016 Oct;100(10):2188-93. doi: 10.1097/TP.0000000000001311.
PMID: 27379556DERIVEDClaes KJ, Heye S, Bammens B, Kuypers DR, Meijers B, Naesens M, Vanrenterghem Y, Evenepoel P. Aortic calcifications and arterial stiffness as predictors of cardiovascular events in incident renal transplant recipients. Transpl Int. 2013 Oct;26(10):973-81. doi: 10.1111/tri.12151. Epub 2013 Jul 19.
PMID: 23870026DERIVED
Biospecimen
serum, plasma, urine
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
kathleen Claes, MD
UZ Leuven
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- md
Study Record Dates
First Submitted
October 18, 2007
First Posted
October 19, 2007
Study Start
October 1, 2006
Primary Completion
October 1, 2013
Study Completion
October 1, 2013
Last Updated
October 16, 2018
Record last verified: 2011-10