Serum Cartilage Oligomeric Matrix Protein Levels After 12 Weeks of Different Exercises

NCT01576159 | Completed Early Phase 1 Results DMC

• 2 other identifiers: BAPK06K07K03K00K17107S112
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

Acute effects of physical exercise on the deformational behavior of articular cartilage and changes in cartilage oligomeric matrix protein (COMP) are definite. However, conclusive positive effects of fitness exercise on functional adaptation of articular cartilage have not been proved.Therefore, in this parallel-group randomized control trial, the investigators tested the hypothesis that adequate amount of physical exercise with enough impact would be able to stimulate the functional behavior of articular cartilage. The investigators evaluated 44 healthy males for their physical fitness levels and their blood samples were obtained before, immediately after and 0.5 h after a 30-min walking exercise. Thereafter, participants were assigned to the running, the cycling, the swimming and the control groups. At the end of 12-weeks of intervention, same measurement procedures were applied. Mixed repeated-measures ANOVA design was used for statistics. (Level of evidence: 2)

Conditions

Osteoarthritis; Articular Cartilage Disorder of Knee; Degenerative Lesion of Articular Cartilage of Knee

Keywords

Biochemical Marker; Fitness Exercises; Impact; Articular Cartilage

Outcome Measures

Primary Outcomes (1)

• Changes in Serum COMP Accumulation, Triggered by Acute Exercise, After 12 Weeks of Different Regular Exercises

  Baseline and 12 weeks

Secondary Outcomes (2)

• Physical (Body Mass Index) Changes of Participants

  Baseline and 12 weeks

• Physiological (Maximum Oxygen Consumption) Changes of Participants

  Baseline and 12 weeks

Study Arms (4)

High-Impact Loading

EXPERIMENTAL

Performed high-impact running exercise during intervention period.

Other: Running exercise

Moderate-Impact Loading

EXPERIMENTAL

Performed moderate-impact cycling exercise during intervention period.

Other: Cycling exercise

Non-Impact Loading

EXPERIMENTAL

Performed low-impact swimming exercise during intervention period.

Other: Swimming Exercise

Control Group

NO INTERVENTION

Didn't participate any organized physical exercises

Interventions

Running exercise OTHER

During this type of exercise intervention, subjects performed weight-bearing exercise. This group participated in sessions of 40-min per day, three days per week, for a period of 12 weeks

High-Impact Loading

Cycling exercise OTHER

During this type of exercise intervention, subjects performed a partial weight-bearing exercise. This group participated in sessions of 40-min per day, three days per week, for a period of 12 weeks

Moderate-Impact Loading

Swimming Exercise OTHER

During this type of exercise intervention, subjects performed a non-weight bearing exercise. This group participated in sessions of 40-min per day, three days per week, for a period of 12 weeks

Non-Impact Loading

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• body mass index lower than 30
• availability of participants for the tests and attendance to training sessions

You may not qualify if:

• osteoarthritis, rheumatoid arthritis or other inflammatory joint disease
• intra-articular steroid injection
• mal-alignment of the knees (varus/valgus) larger than 15°
• recent (within six months) fracture of lower extremity.

Sponsors & Collaborators

• Middle East Technical University: lead

Study Sites (1)

Middle East Technical University, Medical Center and Physical Education and Sports Dep.

Ankara, Cankaya, 06531, Turkey (Türkiye)

Location

Related Publications (6)

• Mundermann A, Dyrby CO, Andriacchi TP, King KB. Serum concentration of cartilage oligomeric matrix protein (COMP) is sensitive to physiological cyclic loading in healthy adults. Osteoarthritis Cartilage. 2005 Jan;13(1):34-8. doi: 10.1016/j.joca.2004.09.007.

  PMID: 15639635 BACKGROUND

• Andersson ML, Thorstensson CA, Roos EM, Petersson IF, Heinegard D, Saxne T. Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritis. BMC Musculoskelet Disord. 2006 Dec 7;7:98. doi: 10.1186/1471-2474-7-98.

  PMID: 17156423 BACKGROUND

• Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007 May;39(2):175-91. doi: 10.3758/bf03193146.

  PMID: 17695343 BACKGROUND

• Johnson EP. ACSM's Guidelines for Exercise Testing and Prescription. 6th ed. Baltimore: Lippincott, Williams and Wilkins, 2000.

  RESULT

• Bompa TO. Periodization : theory and methodology ot training. Champaign, IL: Human Kinetics, 1999.

  RESULT

• Field AP. Discovering Statistics Using SPSS for Windows: Advanced Techniques for Beginners. London: Sage Publications, Inc., 2000

  RESULT

MeSH Terms

Conditions

Osteoarthritis; Tooth, Impacted

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases; Tooth Diseases; Stomatognathic Diseases

Results Point of Contact

• Title: Ozgur Celik PhD.
• Organization: Middle East Technical University

ozgur@udel.edu

+903122104016

Study Officials

• Ozgur Celik, PhD

  Middle East Technical University

  STUDY DIRECTOR

• Feza Korkusuz, PhD

  Middle East Technical University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof. Dr.

Study Record Dates

• First Submitted: April 9, 2012
• First Posted: April 12, 2012
• Study Start: January 1, 2008
• Primary Completion: June 1, 2008
• Study Completion: September 1, 2008
• Last Updated: June 10, 2015
• Results First Posted: June 10, 2015

Record last verified: 2015-06

Locations

TU (1)