Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading
1 other identifier
interventional
N/A
0 countries
N/A
Brief Summary
In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.
Trial Health
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Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2008
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2009
CompletedFirst Submitted
Initial submission to the registry
March 18, 2010
CompletedFirst Posted
Study publicly available on registry
March 19, 2010
CompletedMarch 19, 2010
March 1, 2010
7 months
March 18, 2010
March 18, 2010
Conditions
Keywords
Study Arms (2)
Exercise
EXPERIMENTALNon Exercise
PLACEBO COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- verified osteoarthritis (x-ray)of the knee, female,
You may not qualify if:
- dementia, inflammatory diseases, regular pain medication
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Bispebjerg Hospitallead
- The Danish Rheumatism Associationcollaborator
- Danish Ministry of Health, Internal Affairscollaborator
- Danish National Research Councilcollaborator
- The Danish Medical Research Councilcollaborator
Related Publications (1)
Helmark IC, Mikkelsen UR, Borglum J, Rothe A, Petersen MC, Andersen O, Langberg H, Kjaer M. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Arthritis Res Ther. 2010;12(4):R126. doi: 10.1186/ar3064. Epub 2010 Jul 1.
PMID: 20594330DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- early phase 1
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
March 18, 2010
First Posted
March 19, 2010
Study Start
August 1, 2008
Primary Completion
March 1, 2009
Last Updated
March 19, 2010
Record last verified: 2010-03