Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study
1 other identifier
observational
70
1 country
2
Brief Summary
Purpose:Evaluate the feasibility of T2 cartilage mapping on MRI of the wrist and correlate with T2 mapping of knee cartilage. Study protocol: Phase 1. 10 healthy volunteers, Phase 2. 10 volunteers with osteoarthritis of the wrist, Phase 3. 50 patients for studies for routine MR of the wrist. MRI protocol: 3 T unit((Signa EXITE HDx),T1, T2 and T2 mapping sequences on axial and coronal orientation.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 1, 2007
CompletedFirst Submitted
Initial submission to the registry
April 28, 2008
CompletedFirst Posted
Study publicly available on registry
April 30, 2008
CompletedApril 30, 2008
April 1, 2008
April 28, 2008
April 29, 2008
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
wrist bone cartilage thickness can be measured and stratification can be observed on T2 mapping with correlation to T2 mapping of the knee cartilage
Within MRI completion (20 minutes)
Study Arms (3)
1
healthy young volunteers Inclusion: age 18-40, Exclusion: wrist trauma/surgery
2
patients with know osteoarthritis wrist changes according to pre-existing x-rays No age limits exclusion: previous wrist surgery
3
Mixed group of 50 patients that perform routine MRI of the wrist for various indications
Eligibility Criteria
healthy volunteers, volunteers with known osteoarthritis, routine MR population for wrist investigation
You may qualify if:
- Phase 1. Age:18-40
- Phase 2: No age limit, known OA on pre-existing X-rays
- Phase 3: No age limit, routine MRI of the wrist
You may not qualify if:
- Phase 1, 2: wrist trauma/surgery
- All phases: any contraindication for MR: eg metals, claustrophobia, etc.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Sheba Medical Center , Diagnostic Imaging Dept
Tel Litwinsky, Tel Hashomer, 52621, Israel
Sheba Medical Center, Diagnostic Imaging Dept
Tel Litwinsky, Tel Hashomer, 52621, Israel
Related Publications (3)
Glaser C. New techniques for cartilage imaging: T2 relaxation time and diffusion-weighted MR imaging. Radiol Clin North Am. 2005 Jul;43(4):641-53, vii. doi: 10.1016/j.rcl.2005.02.007.
PMID: 15893528BACKGROUNDRecht MP, Goodwin DW, Winalski CS, White LM. MRI of articular cartilage: revisiting current status and future directions. AJR Am J Roentgenol. 2005 Oct;185(4):899-914. doi: 10.2214/AJR.05.0099.
PMID: 16177408BACKGROUNDMosher TJ, Dardzinski BJ, Smith MB. Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2--preliminary findings at 3 T. Radiology. 2000 Jan;214(1):259-66. doi: 10.1148/radiology.214.1.r00ja15259.
PMID: 10644134BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Iris Eshed, MD
Sheba Medical Center
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER GOV
Study Record Dates
First Submitted
April 28, 2008
First Posted
April 30, 2008
Study Start
December 1, 2007
Last Updated
April 30, 2008
Record last verified: 2008-04