NCT01566968|Completed
Novel Endpoints in Cough Challenge Testing
NEAT
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NEAT
Sponsor study identifier
observational
98
1 country
1
Study Start
January 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
April 2012
Actual (reported)Study Completion
April 2012
Actual (reported)The sensitivity of a person's cough reflex can be measured by getting them to breathe in (inhale) irritant chemicals. There are different methods by which subjects are asked to inhale these chemicals, either by taking one deep breath in, or by asking them to just continue to take a number of breaths. The purpose of this clinical research study is to see if the coughing responses are different in healthy people and people with respiratory problems that make them cough when they are given these chemicals in these two methods.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2012
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2011
Date type not reportedThis date has not been verified as actual or estimated.
January 24, 2012
Actual (reported)March 30, 2012
Actual (reported)April 2012
Actual (reported)April 2012
Actual (reported)Adults between ages of 18-75 inclusive who have never smoked and have no history of any respiratory disease for which they are on regular treatment.
Adults between the ages on 18-75 inclusive who have a physician diagnosis of asthma and have no smoking history or minimal smoking history (less than 10 pack years or in other words less than 20 cigarettes per day for 10 years).
Adults between the ages of 18-75 inclusive who have previously been smokers (at least 20 pack years) and have physician diagnosis and spirometry evidence of COPD.
Cough challenge will be performed with Capsaicin, citric acid and prostaglandin E2.
Selected from secondary care.
University Hospital of South Manchester
Manchester, Greater Manchester, M23 9LT, United Kingdom
Saifudin Khalid, MRCP
University Hospital of South Manchester
Ashley Woodcock, MD
University Hospital of South Manchester
98 participants (actual enrollment reported by the registry).
First Submitted
January 24, 2012
First Posted
March 30, 2012
Study Start
January 2011
Date type not reportedThis date has not been verified as actual or estimated.
Effect of Whole Body Periodic Acceleration on Airway Endothelial Function
Adults between the ages of 18-75 inclusive who are currently smokers (at least 10 pack years history)but have no history of any respiratory disease and no evidence of COPD on spirometry.
Adults between ages of 18-75 inclusive who have history of dry cough for at least 8 weeks and have a normal chest x ray and no smoking history or minimal smoking history (less than 10 pack years).
Cough recording by using an ambulatory sound recording device.
questionnaire designed to assess impact of cough on a person's life
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
April 2012
Actual (reported)Study Completion
April 2012
Actual (reported)Last Updated
April 6, 2012
Record last verified: 2012-04
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Source: ClinicalTrials.gov.
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