NCT01297790|Completed
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Sponsor study identifier
observational
102
1 country
1
Study Start
November 2009
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
May 2011
Actual (reported)Study Completion
May 2011
Actual (reported)The sensitivity of a persons cough reflex can be measured by getting them to breath in (inhale) irritant chemicals. The purpose of this clinical research study is to test the sensitivity of the cough reflex to a variety of chemicals that can be inhaled to see if coughing responses are different between healthy people and people with respiratory problems that make them cough.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
May 2011
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 2009
Date type not reportedThis date has not been verified as actual or estimated.
February 15, 2011
Actual (reported)February 17, 2011
Actual (reported)May 2011
Actual (reported)May 2011
Actual (reported)Cough response to tussive agents
To measure cough responses to capsaicin, citric acid, prostaglandin E2 (PGE2) and Bradykinin (BK) in healthy volunteers, airway diseases (asthma and COPD) and chronic cough. To compare the ability of individual challenges and patterns of challenge response to discriminate between diagnostic groups.
45 minutes
Objective cough recording
To perform ambulatory cough recording over 24 hours to assess if there are any differences
24 Hours
C2 to inhaled tussive agents
45 minutes
Subjects with asthma more than 18 years old with minimal or no smoking history and evidence of bronchial hyperreactivity
Subjects with diagnosis of COPD who must be ex smokers and have evidence of airflow obstruction on breathing tests.
Healthy non smoking adults.
Inhalational cough challenge tests with capsaicin, bradykinin, Citric acid and prostaglandin E2
Adults aged 18 and over who are healthy non smokers, or are current smokers with no respiratory conditions and normal spirometry, or have a diagnosis of asthma, chronic cough or COPD.
University Hospital of South Manchester
Manchester, Lancashire, M23 9LT, United Kingdom
Belvisi MG, Birrell MA, Khalid S, Wortley MA, Dockry R, Coote J, Holt K, Dubuis E, Kelsall A, Maher SA, Bonvini S, Woodcock A, Smith JA. Neurophenotypes in Airway Diseases. Insights from Translational Cough Studies. Am J Respir Crit Care Med. 2016 Jun 15;193(12):1364-72. doi: 10.1164/rccm.201508-1602OC.
Sputum.
Ashley A Woodcock, FRCP, MD
University Hospital of South Manchester
102 participants (actual enrollment reported by the registry).
First Submitted
February 15, 2011
First Posted
February 17, 2011
Study Start
November 2009
Date type not reportedThis date has not been verified as actual or estimated.
A Study Assessing Patient Handling of Flutiform® Breath-Actuated Inhaler (BAI) and Flutiform® Pressurised Metered Dose Inhaler (pMDI)
Current smokers with normal breath tests (spirometry)
Subjects with idiopathic chronic cough.
Cough recording with a portable device to capture cough sounds
Questionnaires designed to study cough. These include Leicester cough questionnaire, cough visual analogue score and cough quality of life questionnaire.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
May 2011
Actual (reported)Study Completion
May 2011
Actual (reported)Last Updated
September 16, 2011
Record last verified: 2011-09
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Source: ClinicalTrials.gov.
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