Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment

NCT01559766 | Completed DMC

• 1 other identifier: No.2008BAI58B03
• Study Type: observational
• Target: 403
• Locations: 1 country
• Sites: 1

Brief Summary

Vitamin A deficiency remains a major public health problem in developing country worldwide. Young Children are considered to be at greatest risk of deficiency. However, there is little information on the vitamin A requirement of Chinese children. In the present study, about 400 children aged between 4 and 9 years old in a kindergarten and an elementary school of Shiyan City were screened before admission by questionnaire and anthropometric measurement. The vitamin A status of children was assessed by serum vitamin A level, relative dosage reaction and stable-isotope dilution technique. At the same time, their dietary vitamin A intakes were estimated by weighted-food dietary survey. The dietary vitamin A requirement in young children was determined on the basis of dietary vitamin A intakes in Children with adequate vitamin A level.

Conditions

Vitamin A Deficiency

Keywords

Vitamin A; Dietary requirement; Dietary records; Deuterated retinol dilution technique; Chinese children; Dietary intake of vitamin A; Vitamin A liver reserves

Study Arms (2)

4-6 years old group

7-9 years old group

Eligibility Criteria

• Age: 4 Years - 9 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

The study was carried out in a kindergarten and an elementary school in Shiyan city, Hubei province of China. Initially, 201 kindergarten children (4-6 years old) and 202 grade children (7-9 years old) were subjected to a questionnaire survey on personal information, medical history and dietary habits including dietary supplements.ongoing or previous illnesses, having taken nutritional supplements within 3 months, positive results in the fat absorption test or parasite test, increased level of CRP (\> 8 mg/L), or lower serum level of retinol (\<1.40 umol/L), and higher ratio in relative dosage reaction test(\>20%) .After the screening, 123 children were selected and completed the study, but 60 subjects were randomly selected for the DRD test to evaluate liver vitamin A storage.

You may qualify if:

• well-nourished children with normal serum retinol(\>=1.40umol/L)

You may not qualify if:

• ongoing or previous illnesses,
• having taken nutritional supplements within 3 months,
• positive results in the fat absorption test or parasite test,
• increased level of CRP (\> 8 mg/L), or
• lower serum level of retinol (\< 1.40 umol/L)

Sponsors & Collaborators

• Huazhong University of Science and Technology: lead
• ShiYan Centre for Disease Control and Prevention: collaborator
• Tufts Medical Center: collaborator

Study Sites (1)

Shiyan Centre for Disease Control and Prevention

Shiyan, Hubei, 442500, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

serum

MeSH Terms

Conditions

Vitamin A Deficiency

Condition Hierarchy (Ancestors)

Avitaminosis; Deficiency Diseases; Malnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases

Study Officials

• Xiufa Sun, BS

  Tongji Medical College, Huazhong University of Science and Technology

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 19, 2012
• First Posted: March 21, 2012
• Study Start: July 1, 2009
• Primary Completion: July 1, 2010
• Study Completion: September 1, 2010
• Last Updated: March 21, 2012

Record last verified: 2012-03

Locations

CN (1)