NCT01556256

Brief Summary

This randomized trial studies how well music therapy and parents' education work in improving communication, emotional distress, and recovery in adolescents/young adult patients undergoing treatment for high-risk cancer and their parents. Making a music therapy video may improve communication, emotional distress, and recovery in younger patients undergoing treatment for cancer. It is not yet known whether music therapy and counseling for parents is more effective than information handouts for parents in improving communication and emotional distress in patients undergoing treatment for cancer.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
124

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Apr 2012

Longer than P75 for not_applicable

Geographic Reach
1 country

8 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 15, 2012

Completed
1 day until next milestone

First Posted

Study publicly available on registry

March 16, 2012

Completed
1 month until next milestone

Study Start

First participant enrolled

April 23, 2012

Completed
4.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2016

Completed
7.1 years until next milestone

Study Completion

Last participant's last visit for all outcomes

October 2, 2023

Completed
Last Updated

October 10, 2023

Status Verified

October 1, 2023

Enrollment Period

4.4 years

First QC Date

March 15, 2012

Last Update Submit

October 6, 2023

Conditions

Outcome Measures

Primary Outcomes (17)

  • AYA illness-related distress measured by the Mishel Uncertainty in Illness Scale and the McCorkle Symptom Distress scale

    The MPLUS software will be used to perform latent variable analysis of covariance (ANCOVA) to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA defensive coping measured by the Jalowiec Coping Scale-Revised

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA spiritual perspective measured by the Reed Spiritual Perspective Scale

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA social integration measured by the Perceived Social Support-Family scale, the Perceived Social Support-Friends scale, and the Perceived Social Support-Health Care Providers

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA family environment measured by the Family Adaptability and Cohesion Scale II

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA family environment measured by the Parent-Adolescent Communication scale

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA family environment measured by the Family Strengths Scale

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA positive coping measured by the Jalowiec Coping Scale-Revised

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA hope-derived meaning measured by the Herth Hope Index

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA self-transcendence measured by the Reed Self-Transcendence scale

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • AYA resilience measured by the Nowotny Confidence subscale, the Haase Resilience in Illness Scale, and the Index of Well-Being

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • Parental distress measured by the Perceived Stress Scale, the Profile of Mood States-Short Form, and the Spielberger's State-Trait Anxiety Inventory-State Component

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • Parent family environment measured by the Family Adaptability and Cohesion Scale

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • Parent family environment measured by the Parent-Adolescent Communication scale

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • Parent family environment measured by the Family Strengths Scale

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • Parent family environment measured by the Perceived Social Support-Health Care Providers

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

  • Parent quality of life measured by the Index of Well-being

    The MPLUS software will be used to perform latent variable ANCOVA to account for measurement error and to reduce the number of comparisons.

    Up to 90 days

Study Arms (2)

Arm I (TMV)

EXPERIMENTAL

See detailed description.

Procedure: Music TherapyOther: Quality-of-Life AssessmentOther: Questionnaire Administration

Arm II (TMV+P)

EXPERIMENTAL

See detailed description.

Other: Caregiver-Related Intervention or ProcedureProcedure: Music TherapyOther: Quality-of-Life AssessmentOther: Questionnaire Administration

Interventions

Undergo TMV+P

Arm II (TMV+P)
Music TherapyPROCEDURE

Undergo TMV

Arm I (TMV)

Ancillary studies

Also known as: Quality of Life Assessment
Arm I (TMV)Arm II (TMV+P)

Ancillary studies

Arm I (TMV)Arm II (TMV+P)

Eligibility Criteria

Age11 Years - 24 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • AYA has initial or relapsed cancer diagnosis and is actively on treatment and will continue to be on treatment long enough to complete the intervention and evaluation (4 to 6 weeks)
  • AYA meets at least 1 of 3 criteria indicating potentially high palliative care or end-of-life needs:
  • Any high-risk cancer (i.e., metastatic or stage IV)
  • Receiving moderate- to high-intensity chemotherapy during 3-5 consecutive days in an in- or out-patient setting
  • A diagnosis with an estimated 5-year event-free survival of \< 50%
  • AYA is able to participate in sessions as evaluated by the Karnofsky/Lansky score of 50% or greater
  • One consistent parent is willing and available to participate in all parent and evaluation sessions
  • AYA is not married and has no children
  • AYA and parent are able to read, understand, and speak English

You may not qualify if:

  • Cancers not usually occurring in childhood/adolescent or young adult populations, such as lung or prostate cancer
  • Cognitive impairments that would make it difficult for AYA/parents to participate in the intervention or complete questionnaires (determination in consultation with attending physician, oncologist, and, for adolescents below age 18, the parents)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (8)

Children's Healthcare of Atlanta - Egleston

Atlanta, Georgia, 30322, United States

Location

Children's Healthcare of Atlanta - Scottish Rite

Atlanta, Georgia, 30342, United States

Location

Riley Hospital for Children

Indianapolis, Indiana, 46202, United States

Location

Children's Hospitals and Clinics of Minnesota - Minneapolis

Minneapolis, Minnesota, 55404, United States

Location

Children's Mercy Hospitals and Clinics

Kansas City, Missouri, 64108, United States

Location

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

Location

Cook Children's Medical Center

Fort Worth, Texas, 76104, United States

Location

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States

Location

MeSH Terms

Conditions

Neoplasms

Interventions

Music Therapy

Intervention Hierarchy (Ancestors)

Sensory Art TherapiesComplementary TherapiesTherapeuticsRehabilitationAftercareContinuity of Patient CarePatient CarePsychotherapyBehavioral Disciplines and Activities

Study Officials

  • Joan E Haase

    Children's Oncology Group

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 15, 2012

First Posted

March 16, 2012

Study Start

April 23, 2012

Primary Completion

August 31, 2016

Study Completion

October 2, 2023

Last Updated

October 10, 2023

Record last verified: 2023-10

Locations