STA-9090(Ganetespib) in Patients With Unresectable Stage III or Stage IV Melanoma

NCT01551693 | Terminated Phase 2 Results DMC FDA Drug

• 1 other identifier: 11-039
• Study Type: interventional
• Target: 3
• Locations: 1 country
• Sites: 1

Brief Summary

STA9090 is a drug which inactivates or blocks the work of a protein called Heat Shock Protein 90 or HSP90. HSP90 is a protein that helps some molecules inside your cells to have the right shape. By stopping HSP90's activity, those molecules never get to have the right structure of be functional and they are destroyed. The investigators believe that if they stop the activity of HSP90, the rapidly dividing cells that are in your tumor(s) may slow down. In this research study the investigators are looking to see how well STA9090 works in stopping the spread of your melanoma.

Conditions

Melanoma

Keywords

Stage III; Stage IV; Unresectable; Metastatic

Outcome Measures

Primary Outcomes (1)

• 6-month Progression-Free Survival Rate

  6-month progression-free survival rate was defined as the proportion of patients absent death or progression based on Response Evaluation Criteria In Solid Tumors Criteria (RECIST) before 6 months. Per RECIST 1.0 criteria: progressive disease (PD) is at least a 20% increase in the sum of longest diameter (LD) of target lesions taking as reference the smallest sum LD recorded since the treatment started or the appearance of one or more new lesions. PD for the evaluation of non-target lesions is the appearance of one or more new lesions and/or unequivocal progression of non-target lesions.

  Disease was evaluated radiologically at baseline and every 8 weeks on treatment; Treatment continued until evidence of disease progression or unacceptable toxicity. Relevant for this endpoint was disease status at 6 months.

Secondary Outcomes (2)

• Best Overall Response

  Disease was evaluated radiologically at baseline and every 8 weeks on treatment. Median (range) treatment duration was 1 cycle/4 weeks (1-2 cycles; 4-8 weeks).

• Overall Survival

  Patients were followed every 4 weeks for survival until death, lost to follow-up or study closure (approximately 6 months after the last patient ended treatment). In this study cohort, patients were followed up to 13 weeks.

Study Arms (2)

STA-9090 Cohort A

EXPERIMENTAL

Patients enrolled into two possible cohorts based on tumor expression of BRAF: Cohort A - BRAF mutant disease or Cohort B - BRAF wild type. Cohort A patients received STA-9090 200 mg/m2 once weekly (d1, 8, 15 of 28 day cycle). Patients were treated until evidence of disease progression, unacceptable toxicity, intercurrent illness or withdrawal.

Drug: STA-9090

STA-9090 Cohort B

EXPERIMENTAL

Patients enrolled into two possible cohorts based on tumor expression of BRAF: Cohort A - BRAF mutant disease or Cohort B - BRAF wild type. Cohort B patients received STA-9090 150 mg/m2 twice weekly (d1, 4, 8, 11, 15, 18 of 28 day cycle). Patients were treated until evidence of disease progression, unacceptable toxicity, intercurrent illness or withdrawal.

Drug: STA-9090

Interventions

STA-9090 DRUG

Also known as: Ganetespib

STA-9090 Cohort A; STA-9090 Cohort B

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

* Histologically confirmed unresectable stage III or stage IV melanoma * Treatment of unresectable stage III or stage IV melanoma with a tyrosine kinase inhibitor within prior 4 months. Sorafenib for purposes of eligibility will not be considered acceptable prior therapy * Sufficient tumor available to determine if expresses wild-type or mutated BRAF if result not already known. The presence or absence of BRAF mutation needs to be determined at BWH, MGH, BIDMC, by Drs. Christopher Corless and Michael Heinrich at Cancer Pathology Shared Resource Oregon Health \& Science University, or in context of eligibility assessment after signing consent to a previous clinical trial * Sufficient tumor available to determine if expresses a mutation KIT * Agreement to allow tumor to be evaluated for mutations in KIT and BRAF * ECOG performance status ≤ 1 * Life expectancy of ≥ 6 months * Age ≥ 18 years * WBC ≥ 3 x 103/ul * ANC ≥ 1,500/ul * Platelets ≥ 100 x 103/ul * Hemoglobin ≥ 9 gm/dl * Serum creatinine ≤ 1.5 x ULN * Calculated creatinine clearance ≥ 60 mL/min * AST ≤ 2.5 x ULN; -OR- AST ≤ 5 x ULN in the presence of known liver metastases * ALT ≤ 2.5 x ULN; -OR- ALT ≤ 5 x ULN in the presence of known liver metastases * Total bilirubin ≤ 1.5 x ULN * Potassium within normal range or correctable with supplements * Magnesium within normal range or correctable with supplements * Corrected serum calcium within normal range, or correctable with supplements * Not pregnant or breastfeeding. Female subjects of childbearing age must have a negative serumpregnancy test at study entry * Women of childbearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation and for 6 months following last study drug administration * Agreement to provide blood samples for pharmacodynamic studies utilizing Peripheral Blood Mononuclear Cells (PMBCs) as outlined in protocol * At least one site of measurable disease as defined by at least 1 cm in greatest dimension. This site must be different from the sites to be used for biopsy. No prior radiation therapy or directed ablation to the site of measureable disease * Able to understand and willing to sign a written informed consent document * Willing and able to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures * No chemotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to study entry * No radiotherapy within 4 weeks prior to study entry * Subject has recovered from adverse events due to agents administered more than 4 weeks earlier * No tyrosine kinase inhibitor within 14 days prior to study entry * No major surgery within 4 weeks prior to first dose of STA-9090 * No minor surgery within 7 days of first dose of STA-9090 * No history of or current coronary artery disease, myocardial infarction, angina pectoris, angioplasty * or coronary bypass surgery * No current treatment with the following antiarrythmic drugs: flecainide, moricizine or propafenone * No NYHA class II/III/IV congestive heart failure with a history of dyspnea, orthopnea, or edema that requires current treatment with angiotensin convering enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, or diuretics * No current or prior radiation to the left hemithorax * No embolization procedure or ablation procedure to treat tumor within 4 weeks of first dose of STA- 9090 * Not receiving any other investigational agents * No poor venous access for study drug administration unless subject can use silicone based catheters * No history of brain metastases or of leptomeningeal involvement * No history of severe allergic reactions or hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to STA-9090 (e.g. olyethylene glycol \[PEG\] 300 or Polysorbate 80) * Baseline QTc ≤ 470 msec * No previous history of QT prolongation while taking other medications * Ventricular ejection fraction (EF) \> 55% * No treatment with chronic immunosuppressants * No melanoma of ocular primary * No prior treatment with hsp90 inhibitor * No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, ventricular arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements * No other medications, or severe acute/chronic medical of psychiatric conditions or laboratory abnormality that may increase the risk associated with the study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the subject inappropriate for entry into the study * No history of a different malignancy except for the following circumstances. Individuals with a history of other malignancies are eligible if they have been disease-free for at least 5 years and are deemed by the investigator to be at low risk for recurrence of that malignancy. Individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin * No HIV-positive subject on combination antiretroviral therapy * No more than 3 prior systemic therapies for unresectable stage III or stage IV melanoma * No concomitant use of medications associated with a high incidence of QT prolongation as outlined

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Dana-Farber Cancer Institute: lead
• Synta Pharmaceuticals Corp.: collaborator

Study Sites (1)

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States

Location

MeSH Terms

Conditions

Melanoma; Neoplasm Metastasis

Interventions

STA 9090

Condition Hierarchy (Ancestors)

Neuroendocrine Tumors; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Nerve Tissue; Nevi and Melanomas; Skin Neoplasms; Neoplasms by Site; Skin Diseases; Skin and Connective Tissue Diseases; Neoplastic Processes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Limitations and Caveats

The study was terminated early due to weak accrual.

Results Point of Contact

• Title: F. Stephen Hodi, MD
• Organization: Dana-Farber Cancer Institute

Stephen_Hodi@dfci.harvard.edu

617.632.5053

Study Officials

• F. Stephen Hodi, M.D.

  Dana-Farber Cancer Institute

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Melanoma Disease Center Director

Study Record Dates

• First Submitted: April 29, 2011
• First Posted: March 13, 2012
• Study Start: September 1, 2011
• Primary Completion: September 1, 2012
• Study Completion: September 1, 2012
• Last Updated: April 12, 2017
• Results First Posted: April 12, 2017

Record last verified: 2017-01

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)