NCT01547793|Completed
Carbon Monoxide Levels and Sickle Cell Disease Severity
End-Alveolar Carbon Monoxide as a Measure of Erythrocyte Survival and Hemolytic Severity in Sickle Cell Disease
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End-Alveolar Carbon Monoxide as a Measure of Erythrocyte Survival and Hemolytic Severity in Sickle Cell Disease
Sponsor study identifier
Secondary identifiers
observational
106
1 country
1
Study Start
January 26, 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
Not reported
Date not reportedStudy Completion
November 4, 2015
Date type not reportedThis date has not been verified as actual or estimated.
Background: \- Some people with sickle cell disease have different health problems than others. This may be related to how easily and frequently the red blood cells break apart in the blood. Researchers want to test breath and blood samples from people with sickle cell disease to look for very small amounts of carbon monoxide, which is produced when red blood cells break apart. They will compare these results with breath samples from healthy volunteers. Studying different levels of carbon monoxide may help predict what health problems a person with sickle cell disease may get. It may also provide more information on possible treatments. Objectives: \- To study breath carbon monoxide levels and their possible relation to the severity of sickle cell disease. Eligibility:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
November 4, 2015
Date type not reportedThis date has not been verified as actual or estimated.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 26, 2012
Date type not reportedThis date has not been verified as actual or estimated.
March 6, 2012
Actual (reported)March 8, 2012
Actual (reported)November 4, 2015
Date type not reportedThis date has not been verified as actual or estimated.
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892, United States
CROSBY WH. The metabolism of hemoglobin and bile pigment in hemolytic disease. Am J Med. 1955 Jan;18(1):112-22. doi: 10.1016/0002-9343(55)90208-4. No abstract available.
Hebbel RP. Reconstructing sickle cell disease: a data-based analysis of the "hyperhemolysis paradigm" for pulmonary hypertension from the perspective of evidence-based medicine. Am J Hematol. 2011 Feb;86(2):123-54. doi: 10.1002/ajh.21952.
John F Tisdale, M.D.
National Heart, Lung, and Blood Institute (NHLBI)
106 participants (actual enrollment reported by the registry).
First Submitted
March 6, 2012
First Posted
March 8, 2012
Study Start
January 26, 2012
Date type not reportedThis date has not been verified as actual or estimated.
Microvascular Blood Flow in Sickle Cell Anemia
Contact the study team to confirm eligibility.
Platt OS, Brambilla DJ, Rosse WF, Milner PF, Castro O, Steinberg MH, Klug PP. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med. 1994 Jun 9;330(23):1639-44. doi: 10.1056/NEJM199406093302303.
van Vuren AJ, Minniti CP, Mendelsohn L, Baird JH, Kato GJ, van Beers EJ. Lactate dehydrogenase to carboxyhemoglobin ratio as a biomarker of heme release to heme processing is associated with higher tricuspid regurgitant jet velocity and early death in sickle cell disease. Am J Hematol. 2021 Sep 1;96(9):E315-E318. doi: 10.1002/ajh.26243. Epub 2021 Jun 10. No abstract available.
Study Completion
November 4, 2015
Date type not reportedThis date has not been verified as actual or estimated.
Last Updated
April 5, 2019
Record last verified: 2015-11-04
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Source: ClinicalTrials.gov.
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