NCT01545115

Brief Summary

Longitudinal survey in Northern Senegal to investigate the environmental factors modulating the immune response to childhood vaccines and to malaria. A cohort of 410 children aged 1 to 10 from 5 villages of the Senegal River Valley(Podor District) was followed-up for 18 months. During that period, 5 visits have been made to the villages to assess the immunological and nutritional status of the children.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
410

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Oct 2008

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2008

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2010

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2010

Completed
2.1 years until next milestone

First Submitted

Initial submission to the registry

February 29, 2012

Completed
6 days until next milestone

First Posted

Study publicly available on registry

March 6, 2012

Completed
Last Updated

March 13, 2012

Status Verified

March 1, 2012

Enrollment Period

1.3 years

First QC Date

February 29, 2012

Last Update Submit

March 12, 2012

Conditions

Whooping CoughMalariaMalnutrition

Keywords

ChildrenImmunitySub-SaharanPertussisMalariaNutritionantibodies

Eligibility Criteria

Age1 Year - 10 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17)
Sampling MethodNon-Probability Sample
Study Population

Residents of 5 villages from the Senegal Valley River, belonging to the Podor District in Saint-Louis Region in Northern Senegal. Agniam (16°32'N-14°48'W; total population (TP): 989; several temporary ponds, traditional housing, irrigated crops) Fanaye Diery (16°32'N-15°13'W; TP: 6781; animal husbandry, irrigated crops, some urbanized habitat) Niandane (16°35'N-14°59'W; TP: 5100; Rice and banana farming, irrigated crops, some urbanized habitat) Ndiayène Pendao (16°30'N- 15°03'W; TP: 2734; animal husbandry, Savannah surroundings) Guédé Village (16°33'N-14°48'W; TP:3005; Traditional housing, irrigated crops)

You may qualify if:

  • Age: between 1 and 10 years

You may not qualify if:

  • Fever (body temperature superior to 38.5 °C)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Biomedical Research Center EPLS

Saint-Louis, Saint-Louis, BP 56, Senegal

Location

Related Publications (2)

  • Ndiath MO, Sarr JB, Gaayeb L, Mazenot C, Sougoufara S, Konate L, Remoue F, Hermann E, Trape JF, Riveau G, Sokhna C. Low and seasonal malaria transmission in the middle Senegal River basin: identification and characteristics of Anopheles vectors. Parasit Vectors. 2012 Jan 23;5:21. doi: 10.1186/1756-3305-5-21.

    PMID: 22269038BACKGROUND

  • Gaayeb L, Pincon C, Cames C, Sarr JB, Seck M, Schacht AM, Remoue F, Hermann E, Riveau G. Immune response to Bordetella pertussis is associated with season and undernutrition in Senegalese children. Vaccine. 2014 Jun 5;32(27):3431-7. doi: 10.1016/j.vaccine.2014.03.086. Epub 2014 Apr 14.

    PMID: 24726248DERIVED

Related Links

Biospecimen

Retention: SAMPLES WITHOUT DNA

Sera, culture supernatants

MeSH Terms

Conditions

Whooping CoughMalariaMalnutrition

Condition Hierarchy (Ancestors)

Bordetella InfectionsGram-Negative Bacterial InfectionsBacterial InfectionsBacterial Infections and MycosesInfectionsRespiratory Tract InfectionsRespiratory Tract DiseasesProtozoan InfectionsParasitic DiseasesMosquito-Borne DiseasesVector Borne DiseasesNutrition DisordersNutritional and Metabolic Diseases

Study Officials

  • Franck Remoué, PhD

    Biomedical Research Center EPLS

    STUDY CHAIR

  • Emmanuel Hermann, PhD A. Pr.

    Biomedical Research Center

    STUDY DIRECTOR

  • Jean Biram Sarr, PhD

    Biomedical Research Center EPLS

    PRINCIPAL INVESTIGATOR

  • Lobna Gaayeb, VetMed

    Biomedical Research Center EPLS

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 29, 2012

First Posted

March 6, 2012

Study Start

October 1, 2008

Primary Completion

February 1, 2010

Study Completion

February 1, 2010

Last Updated

March 13, 2012

Record last verified: 2012-03

Locations

SE(1)