Pakistan Flocculent Health Outcome Study
1 other identifier
interventional
8,949
1 country
1
Brief Summary
This study is designed to evaluate the effect of different methods of drinking water treatment on the occurrence of diarrhea among children living in squatter settlements in Karachi, Pakistan, and the marginal benefit of adding handwashing to water treatment. 260 households will receive a new product which combines flocculation with chlorination to produce clearer, less chemically contaminated drinking water. 260 households will receive dilute sodium hypochlorite, i.e. bleach to treat their water. 260 households will receive soap and encouraged to wash their hands regularly. 260 households will receive both soap and the combination flocculation/chlorination water treatment. 260 households will continue their standard water treatment and handwashing practices. The households will be visited each week for 9 months, and the episodes of diarrhea from each child in the household recorded. The rate of diarrhea between the groups will be compared. At the end of 9 months, households who were part of the standard habits and practice group will receive a water storage vessel and disinfectant.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Mar 2003
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2003
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2004
CompletedFirst Submitted
Initial submission to the registry
February 21, 2012
CompletedFirst Posted
Study publicly available on registry
February 27, 2012
CompletedFebruary 27, 2012
February 1, 2012
9 months
February 21, 2012
February 24, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
diarrhea longitudinal prevalence
Study Arms (5)
Handwashing
EXPERIMENTALparticipants received weekly, in-home handwashing promotion and soap as needed
handwashing and water treatment
EXPERIMENTALWater treatment with sodium hypochlorite
EXPERIMENTALWater treatment with flocculent-disinfectant
EXPERIMENTALparticipants received a supply of flocculent-disinfectant product and instruction to use it to treat drinking water
Control
NO INTERVENTIONInterventions
participants received weekly in-home handwashing promotion and soap as needed
participants received a supply of flocculent-disinfectant product for water treatment and instruction in how to use it
participants received a supply of dilute sodium hypochlorite and instruction to treat drinking water with it
Eligibility Criteria
You may qualify if:
- households in study neighborhoods
- contain a child \< 5 years old
- have access to water for handwashing
You may not qualify if:
- participated in handwashing or drinking water treatment programs with HOPE previously
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Centers for Disease Control and Preventionlead
- Health Oriented Preventive Educationcollaborator
- Procter and Gamblecollaborator
Study Sites (1)
Health-Oriented Preventive Education
Karachi, Pakistan
Related Publications (3)
Luby SP, Agboatwalla M, Painter J, Altaf A, Billhimer W, Keswick B, Hoekstra RM. Combining drinking water treatment and hand washing for diarrhoea prevention, a cluster randomised controlled trial. Trop Med Int Health. 2006 Apr;11(4):479-89. doi: 10.1111/j.1365-3156.2006.01592.x.
PMID: 16553931RESULTBoudier E, Zurlinden B, Cour A, Rognon M, Devalland-Monnin C, Nirhy-Lanto A, el Khadissi H. [Antenatal diagnosis of achondrogenesis. Two successive cases in the same family]. J Gynecol Obstet Biol Reprod (Paris). 1991;20(5):623-6. French.
PMID: 1955657RESULTBowen A, Agboatwalla M, Luby S, Tobery T, Ayers T, Hoekstra RM. Association between intensive handwashing promotion and child development in Karachi, Pakistan: a cluster randomized controlled trial. Arch Pediatr Adolesc Med. 2012 Nov;166(11):1037-44. doi: 10.1001/archpediatrics.2012.1181.
PMID: 22986783DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 21, 2012
First Posted
February 27, 2012
Study Start
March 1, 2003
Primary Completion
December 1, 2003
Study Completion
January 1, 2004
Last Updated
February 27, 2012
Record last verified: 2012-02