Longitudinal Study of People Presenting for First Treatment of a Mood Disorder

NCT01529905 | Unknown

• 1 other identifier: 99-1715
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this project is to study the course and outcome of illness in individuals who present with a first episode of depression or mania, or who have a recurrent disorder but have never received treatment. We plan to examine psychological, physical, social and environmental factors that may affect long-term outcome in these disorders

Conditions

Major Depression; Bipolar Disorder

Keywords

depression; mania; bipolar; outcome; cognitive

Eligibility Criteria

• Age: 16 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

patients who present to a tertiary care clinic for first treatment of depression or mania

You may qualify if:

• Primary Mood Disorder,
• Age 16-50
• No previous treatment with psychotropic medication (may have had a max. of 5 days treatment with antidepressants/mood stabilizer \&/or they may have Haldol \&/or Lorazepam for clear restraint)

You may not qualify if:

• History of CNS illness (except migraines),
• Thyroid Disease,
• Neoplastic illness
• History of, or currently being treated for, Anorexia or Bulimia
• History of Traumatic Brain Injury
• Current treatment of Attention-Deficit Hyperactivity Disorder (ADHD)
• Previous diagnosis of OCD or primary Anxiety disorder
• Axis-II diagnosis that would suggest non-responsiveness to pharmacotherapy.
• Substance dependence

Sponsors & Collaborators

• McMaster University: lead
• Ontario Mental Health Foundation: collaborator
• Canadian Institutes of Health Research (CIHR): collaborator
• AstraZeneca: collaborator

Study Sites (1)

St. Joseph's Healthcare, Centre for Mountain Health Services

Hamilton, Ontario, L8N 3K7, Canada

RECRUITING

Related Publications (3)

• Judd LL, Akiskal HS, Maser JD, Zeller PJ, Endicott J, Coryell W, Paulus MP, Kunovac JL, Leon AC, Mueller TI, Rice JA, Keller MB. A prospective 12-year study of subsyndromal and syndromal depressive symptoms in unipolar major depressive disorders. Arch Gen Psychiatry. 1998 Aug;55(8):694-700. doi: 10.1001/archpsyc.55.8.694.

  PMID: 9707379 BACKGROUND

• Solomon DA, Keller MB, Leon AC, Mueller TI, Shea MT, Warshaw M, Maser JD, Coryell W, Endicott J. Recovery from major depression. A 10-year prospective follow-up across multiple episodes. Arch Gen Psychiatry. 1997 Nov;54(11):1001-6. doi: 10.1001/archpsyc.1997.01830230033005.

  PMID: 9366656 BACKGROUND

• Mueller TI, Keller MB, Leon AC, Solomon DA, Shea MT, Coryell W, Endicott J. Recovery after 5 years of unremitting major depressive disorder. Arch Gen Psychiatry. 1996 Sep;53(9):794-9. doi: 10.1001/archpsyc.1996.01830090040006.

  PMID: 8792756 BACKGROUND

MeSH Terms

Conditions

Depressive Disorder, Major; Bipolar Disorder; Depression; Mania

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders; Bipolar and Related Disorders; Behavioral Symptoms; Behavior; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Glenda MacQueen, MD, PhD

  McMaster University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Helen Begin, RN

CONTACT

905-522-1155; hbegin@stjosham.on.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 7, 2012
• First Posted: February 9, 2012
• Study Start: June 1, 1999
• Primary Completion: September 1, 2009
• Study Completion: June 1, 2014
• Last Updated: February 9, 2012

Record last verified: 2005-06

Locations

CA (1)