NCT01522248|CompletedResults
Early Immune Responses to Inactivated Influenza Vaccine: a Pilot Study
A Pilot Study to Examine the Early Cytokine Responses After Inactivated Influenza Vaccination in Adults 18-50.
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Sponsor study identifier
interventional
20
1 country
1
Study Start
January 2012
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2012
Actual (reported)Study Completion
February 2012
Actual (reported)Some people experience symptoms just after receiving the seasonal inactivated influenza vaccine. The cause of some of these symptoms is likely to be an immune response to the vaccine. The investigators would like to look at the earliest immune responses to the inactivated influenza vaccine. This pilot study will help us to determine at what time points we should look.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2012
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2012
Date type not reportedThis date has not been verified as actual or estimated.
January 27, 2012
Actual (reported)January 31, 2012
Actual (reported)February 2012
Actual (reported)February 2012
Actual (reported)March 15, 2019
Actual (reported)Levels of Cytokine Interferon Gamma (IFN-gamma) Responses to Inactivated Influenza Vaccine
This was an exploratory trial to look at the kinetics of early cytokine response to influenza vaccine. Serum collected was assessed for cytokines, and PBMCs may be assessed for innate and adaptive immune responses, as well as for genetic markers associated with immune responses to vaccination. Data for Cohort 1 reported as 0 hours and 24 hours. Data for Cohort 2 reported as 0 hours and 16 hours. Data was combined for the Cohorts and reported as 0 hours (baseline) and 14 days.
0 hours, 16 hours, 24 hours, 14 days
Levels of Cytokine Interleukin 8 (IL-8) Cytokine Response to Inactivated Influenza Vaccine
This was an exploratory trial to look at the kinetics of early cytokine response to influenza vaccine. Serum collected was assessed for cytokines, and PBMCs may be assessed for innate and adaptive immune responses, as well as for genetic markers associated with immune responses to vaccination. Data for Cohort 1 reported as 0 hours and 24 hours. Data for Cohort 2 reported as 0 hours and 16 hours. Data was combined for the Cohorts and reported as 0 hours (baseline) and 14 days.
0 hours, 16 hours, 24 hours, 14 days
Levels of Cytokine Interferon Induced Gamma Protein (IP-10) Responses to Inactivated Influenza Vaccine
This was an exploratory trial to look at the kinetics of early (1st 48 hours) cytokine response to influenza vaccine. Serum collected was assessed for cytokines, and PBMCs may be assessed for innate and adaptive immune responses, as well as for genetic markers associated with immune responses to vaccination. Data for Cohort 1 reported as 0 hours and 24 hours. Data for Cohort 2 reported as 0 hours and 16 hours. Data was combined for the Cohorts and reported as 0 hours (baseline) and 14 days.
0 hours, 16 hours, 24 hours, 14 days
receives vaccine in morning. Blood drawn at 3, 7, 24, and 48 hours and 14 days after vaccination.
receives vaccine in evening, Blood drawn 16, 40 hours and 14 days after vaccination.
0.5 ml IM once only
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Johns Hopkins Center for Immunization Research
Baltimore, Maryland, 21205, United States
Talaat KR, Halsey NA, Cox AB, Coles CL, Durbin AP, Ramakrishnan A, Bream JH. Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination. Influenza Other Respir Viruses. 2018 Mar;12(2):202-210. doi: 10.1111/irv.12509. Epub 2018 Jan 4.
Kawsar Talaat, MD
Johns Hopkins Bloomberg School of Public Health
20 participants (actual enrollment reported by the registry).
First Submitted
January 27, 2012
First Posted
January 31, 2012
Study Start
January 2012
Date type not reportedThis date has not been verified as actual or estimated.
Effect of a Multi-strain Probiotic Formulation on Immune Response to Influenza Vaccination
Contact the study team to confirm eligibility.
Primary Completion
February 2012
Actual (reported)Study Completion
February 2012
Actual (reported)Last Updated
March 15, 2019
Results First Posted
March 15, 2019
Record last verified: 2019-03
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Source: ClinicalTrials.gov.
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