Age-Related Changes in Body Composition

NCT01517113 | Terminated

• 2 other identifiers: 12001912-AG-0019
• Study Type: observational
• Target: 24
• Locations: 1 country
• Sites: 2

Brief Summary

Background: \- Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age. Studies suggest that age-related inflammation may affect fatty tissue in the body. If this fat develops in the muscles or around the heart, it may increase risks of heart disease. Researchers will study body composition in older adults to see if age-related changes in body fat are related to higher risks of heart disease. Objectives: \- To study the relationship between fat deposits and aging, and greater risks of heart disease. Eligibility:

• Participants in the Baltimore Longitudinal Study of Aging between 50 and 80 years of age.
• Individuals between 50 and 80 years of age who have been diagnosed with coronary artery disease. Design:
• Participants will be screened with a physical exam and medical history.
• Participants will provide blood and urine samples. They will also have their height and weight measured. Waist circumference will also be taken.
• Participants will have a DEXA scan to study their muscles.
• Participants will have magnetic resonance imaging scans. These scans will study heart function and muscle and blood vessel health.
• Participants with coronary artery disease will have catheterization. Blood samples will be collected during the procedure....

Conditions

Hypertension; Atherosclerosis

Keywords

Endothelial Dysfunction; Hepatic; Adiposity; Cytokines; Muscle Mass; Coronary Artery Disease; Aging; Inflammation

Eligibility Criteria

• Age: 50 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 50-90 years
• Body mass index greater than or equal to 20 and less than or equal to 35
• Weight is less than 300 lbs
• In addition, for CAD participants (Group B):
• Catheterization-documented coronary artery disease, defined as greater than or equal to 70% stenosis in a major epicardial coronary artery, or greater than or equal to 50% stenosis of the left main coronary artery OR
• Prior myocardial infarction defined by ischemic symptoms associated with ECG changes and enzyme elevation.
• In addition, for CAD participants in whom arterial and hepatic vein inflammatory mediators will be obtained:
• \- Scheduled for clinically indicated right or left heart catheterization, no contraindication for the procedure, and consented to the research procedure.

You may not qualify if:

• Known inflammatory disease
• Known liver disease
• Abnormal liver function tests defined by enzyme rise to greater than three times the upper limit of normal.
• Contraindications to the performance of MRI scans
• Chronic use of anti-inflammatory agents other than low dose aspirin (81mg). Chronic use is defined here as the inability to stop taking their anti-inflammatory agent for at least one week before starting this study
• Pregnant or lactating
• In addition, for BLSA participants:
• \- Known coronary artery disease by prior history, examination, or resting or stress electrocardiogram testing.
• In addition, for CAD participants undergoing arterial and hepatic vein inflammatory mediator sampling:
• Receiving therapy with heparin, a glycoprotein IIB/IIIA inhibitor, or bivalirudin
• History of atrial fibrillation
• Presence of an inferior vena cava filter
• Deep venous thrombosis
• Active infection.

Sponsors & Collaborators

• National Institute on Aging (NIA): lead

Study Sites (2)

Johns Hopkins University

Baltimore, Maryland, 21205, United States

Location

National Institute of Aging, Clinical Research Unit

Baltimore, Maryland, 21224, United States

Location

Related Publications (3)

• Singh T, Newman AB. Inflammatory markers in population studies of aging. Ageing Res Rev. 2011 Jul;10(3):319-29. doi: 10.1016/j.arr.2010.11.002. Epub 2010 Dec 8.

  PMID: 21145432 BACKGROUND

• Ferrucci L, Corsi A, Lauretani F, Bandinelli S, Bartali B, Taub DD, Guralnik JM, Longo DL. The origins of age-related proinflammatory state. Blood. 2005 Mar 15;105(6):2294-9. doi: 10.1182/blood-2004-07-2599. Epub 2004 Nov 30.

  PMID: 15572589 BACKGROUND

• Brooks GC, Blaha MJ, Blumenthal RS. Relation of C-reactive protein to abdominal adiposity. Am J Cardiol. 2010 Jul 1;106(1):56-61. doi: 10.1016/j.amjcard.2010.02.017. Epub 2010 May 13.

  PMID: 20609648 BACKGROUND

MeSH Terms

Conditions

Hypertension; Atherosclerosis; Obesity; Coronary Artery Disease; Inflammation

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Coronary Disease; Myocardial Ischemia; Heart Diseases; Pathologic Processes

Study Officials

• Luigi Ferrucci, M.D.

  National Institute on Aging (NIA)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 24, 2012
• First Posted: January 25, 2012
• Study Start: January 2, 2012
• Study Completion: October 13, 2017
• Last Updated: April 5, 2018

Record last verified: 2017-10-13

Locations

US (2)