Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging
1 other identifier
observational
18
1 country
1
Brief Summary
The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium channels present in the vessels being operated on, and the genes that may alter blood vessel function. Possible variation in these genes may change the kind of calcium channels present in blood vessels.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Aug 2012
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 8, 2005
CompletedFirst Posted
Study publicly available on registry
November 10, 2005
CompletedStudy Start
First participant enrolled
August 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2012
CompletedAugust 6, 2012
August 1, 2012
Same day
November 8, 2005
August 3, 2012
Conditions
Keywords
Eligibility Criteria
Patients scheduled for vascular surgery
You may qualify if:
- Ages 21 and older
- Scheduled for vascular surgery
You may not qualify if:
- Unwillingness to be subjected to diagnostic and/or therapeutic procedures that are deemed not necessary for clinical management
- Volunteers deemed too fragile to participate in the study by the principal investigator (PI) or the attending physician
- Inability to obtain informed consent from either the volunteer or the responsible party (durable power of attorney \[DPA\]) for the volunteer, with the volunteer's assent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
National Institute on Aging, Harbor Hospital
Baltimore, Maryland, 21225, United States
Related Publications (3)
Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM. New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem. 2004 Nov 5;279(45):46367-72. doi: 10.1074/jbc.M409523200. Epub 2004 Aug 31.
PMID: 15339916BACKGROUNDKobrinsky E, Tiwari S, Maltsev VA, Harry JB, Lakatta E, Abernethy DR, Soldatov NM. Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions. J Biol Chem. 2005 Apr 1;280(13):12474-85. doi: 10.1074/jbc.M412140200. Epub 2005 Jan 25.
PMID: 15671035BACKGROUNDAbernethy DR, Soldatov NM. Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets. J Pharmacol Exp Ther. 2002 Mar;300(3):724-8. doi: 10.1124/jpet.300.3.724.
PMID: 11861774BACKGROUND
Biospecimen
Vascular tissue obtained from the surgical site that would have otherwise been discarded and Blood Serum
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Samer Najjar, MD
National Institute on Aging (NIA)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- NIH
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 8, 2005
First Posted
November 10, 2005
Study Start
August 1, 2012
Primary Completion
August 1, 2012
Study Completion
August 1, 2012
Last Updated
August 6, 2012
Record last verified: 2012-08