Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients

NCT01515033 | Completed Phase 2 DMC

• 1 other identifier: 117/11
• Study Type: interventional
• Target: 37
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of the present study was to evaluate: 1) the effects of continuous exercise training and interval exercise training on end-tidal carbon dioxide pressure (PETCO2) response during graded exercise test in patients with coronary artery disease; and 2) examine the effects of exercise training modalities on the association among PETCO2 at ventilatory anaerobic threshold (VAT) and indicators of ventilatory efficiency and cardiorespiratory fitness in patients with coronary artery disease.

Conditions

Coronary Artery Disease; Exercise Addiction; Complication, Cardio-respiratory

Keywords

Coronary artery disease; Exercise; Ventilatory efficiency

Outcome Measures

Primary Outcomes (1)

• PetCO2 response during graded exercise test

  End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions (1,2). Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation

  before and after 3 months of the interventions

Study Arms (2)

Continuous exercise training

EXPERIMENTAL

The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.

Other: aerobic exercise training

interval exercise training

EXPERIMENTAL

The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes

Other: aerobic exercise training

Interventions

aerobic exercise training OTHER

The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold. The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes

Also known as: continuous training, interval training

Continuous exercise training; interval exercise training

Eligibility Criteria

• Age: 40 Years - 79 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• was stable coronary artery disease diagnosed by coronary angiography

You may not qualify if:

• unstable angina pectoris,
• complex ventricular arrhythmias,
• pulmonary congestion and
• orthopaedic or neurological limitations to exercise

Sponsors & Collaborators

• Hospital TotalCor: lead

MeSH Terms

Conditions

Coronary Artery Disease; Motor Activity

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Danilo ML Prado, Prof.MS

  Hospital TotalCor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MS

Study Record Dates

• First Submitted: January 18, 2012
• First Posted: January 23, 2012
• Study Start: September 1, 2010
• Primary Completion: June 1, 2011
• Study Completion: August 1, 2011
• Last Updated: January 23, 2012

Record last verified: 2012-01