Aerobic Exercise on Ventilatory Efficiency in CAD Patients

NCT02106533 | Completed Phase 2 DMC

• 1 other identifier: 53/2010
• Study Type: interventional
• Target: 123
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of the present study was to test the hypothesis that patients with coronary artery disease with lower aerobic fitness exhibit greater responsiveness on improving ventilatory efficiency after aerobic exercise training.

Conditions

Coronary Artery Disease; Exercise Addiction; Complication, Cardio-respiratory

Keywords

Coronary artery disease; Exercise; Ventilatory efficiency

Outcome Measures

Primary Outcomes (1)

• Ventilatory efficiency in patients with coronary artery disease

  Measurements of ventilatory efficiency during cardiopulmonary exercise testing typically expressed as the minute ventilation/ carbon dioxide production ratio have been validated to be useful in assessing the presence and severity of both heart and lung diseases. In this context, previous studies have showed ventilatory inefficiency in patients with coronary artery disease suggests abnormalities in the distribution of ventilation and perfusion in the lungs.

  up to 3 months of the interventions

Study Arms (3)

Group 1 peak VO2 <17.5 ml/kg/min

EXPERIMENTAL

The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP.

Other: Aerobic exercise training

Group 2 peak VO2 > 17.5 < 24.5 ml/kg/min

EXPERIMENTAL

The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.

Other: Aerobic exercise training

Group 3 peak VO2 > 24.5 ml/kg/min

EXPERIMENTAL

The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill . Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.

Other: Aerobic exercise training

Interventions

Aerobic exercise training OTHER

The exercise training program was comprised of three 60-minute exercise sessions per week over a 3-month period. Each exercise session consisted of a 5 minute warm up, 30-50 minutes of aerobic exercise performed on a treadmill and 5 minutes of cool-down exercises. Aerobic exercise intensity was set at the corresponding heart rate between the VAT and RCP. All patients were able to achieve the set aerobic training intensity.

Group 1 peak VO2 <17.5 ml/kg/min; Group 2 peak VO2 > 17.5 < 24.5 ml/kg/min; Group 3 peak VO2 > 24.5 ml/kg/min

Eligibility Criteria

• Age: 48 Years - 77 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• was stable coronary artery disease diagnosed by coronary angiography

You may not qualify if:

• unstable angina pectoris,
• complex ventricular arrhythmias,
• pulmonary congestion and
• orthopaedic or neurological limitations to exercise

Sponsors & Collaborators

• Hospital TotalCor: lead

Related Publications (1)

• Prado DM, Rocco EA, Silva AG, Silva PF, Lazzari JM, Assumpcao GL, Thies SB, Suzaki CY, Puig RS, Furlan V. The influence of aerobic fitness status on ventilatory efficiency in patients with coronary artery disease. Clinics (Sao Paulo). 2015 Jan;70(1):46-51. doi: 10.6061/clinics/2015(01)09.

  PMID: 25672429 DERIVED

MeSH Terms

Conditions

Coronary Artery Disease; Motor Activity

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Behavior

Study Officials

• Danilo ML Prado, PHD

  Hospital TotalCor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PHD

Study Record Dates

• First Submitted: March 27, 2014
• First Posted: April 8, 2014
• Study Start: August 1, 2011
• Primary Completion: June 1, 2012
• Study Completion: May 1, 2013
• Last Updated: April 8, 2014

Record last verified: 2014-04