Changes in Serum Fibroblast Growth Factor 21 (FGF21) Levels Correlated With Exercise
2 other identifiers
interventional
82
1 country
1
Brief Summary
We evaluated the effect of two weeks of intensive supervised physical activity in serum fibroblast growth factor 21 (FGF21) levels.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Mar 2010
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2011
CompletedFirst Submitted
Initial submission to the registry
January 11, 2012
CompletedFirst Posted
Study publicly available on registry
January 19, 2012
CompletedResults Posted
Study results publicly available
March 26, 2012
CompletedJanuary 14, 2013
January 1, 2013
1.4 years
January 11, 2012
January 20, 2012
January 9, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change From Baseline Fibroblast Growth Factor 21 (FGF21) Acutely and at Two Weeks
Serum measurement of FGF21 using human ELISA kit was done at baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise.
Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise
Secondary Outcomes (5)
Change From Baseline Free Fatty Acids (FFAs) Acutely and at Two Weeks
Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise
Change From Baseline Epinephrine Acutely and at Two Weeks
Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise
Change From Baseline Leptin Acutely and at Two Weeks
Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise
Change From Baseline Total Adiponectin Acutely and at Two Weeks
Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise
Change From Baseline Fasting Glucose Acutely and at Two Weeks
Baseline, 1hr and 4 hr after a bout of exercise, and repeated after two weeks of daily supervised exercise
Study Arms (1)
Supervised exercising
EXPERIMENTALA treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks to participants.
Interventions
A treadmill exercise test (following the Bruce's protocol) was done five times per week (from Monday to Friday) for two weeks.
Eligibility Criteria
You may qualify if:
- Women
- Aged 18 to 35 years old,
- Body mass index (BMI) \<30 kg/m2
- Without contraindication for exercising
You may not qualify if:
- Metabolic syndrome
- Diabetes
- Dyslipidemia
- Hypertension
- Asthma
- Thyroid disease
- Treated with fibrates, beta agonists or blockers
- History or current arrhythmias, murmurs, cardiomegaly, or treatment for cardiovascular diseases -
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
INCMNSZ
Mexico City, Tlalpan, 14000, Mexico
Related Publications (3)
Cuevas-Ramos D, Almeda-Valdes P, Gomez-Perez FJ, Meza-Arana CE, Cruz-Bautista I, Arellano-Campos O, Navarrete-Lopez M, Aguilar-Salinas CA. Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels. Eur J Endocrinol. 2010 Sep;163(3):469-77. doi: 10.1530/EJE-10-0454. Epub 2010 Jun 21.
PMID: 20566587BACKGROUNDHill J, Timmis A. Exercise tolerance testing. BMJ. 2002 May 4;324(7345):1084-7. doi: 10.1136/bmj.324.7345.1084. No abstract available.
PMID: 11991917BACKGROUNDCuevas-Ramos D, Almeda-Valdes P, Meza-Arana CE, Brito-Cordova G, Gomez-Perez FJ, Mehta R, Oseguera-Moguel J, Aguilar-Salinas CA. Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PLoS One. 2012;7(5):e38022. doi: 10.1371/journal.pone.0038022. Epub 2012 May 31.
PMID: 22701542DERIVED
Related Links
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Limitations and Caveats
We cannot fully control other potential sources of physical activity. The results may not be applicable to men. We did not register the caloric consumption during the study.
Results Point of Contact
- Title
- Dr. Daniel Cuevas-Ramos
- Organization
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Study Officials
- PRINCIPAL INVESTIGATOR
Daniel Cuevas-Ramos, MD
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
- PRINCIPAL INVESTIGATOR
Paloma Almeda-Valdes, MD
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
- STUDY DIRECTOR
Carlos A Aguilar-Salinas, MD
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Publication Agreements
- PI is Sponsor Employee
- Yes
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
January 11, 2012
First Posted
January 19, 2012
Study Start
March 1, 2010
Primary Completion
August 1, 2011
Study Completion
November 1, 2011
Last Updated
January 14, 2013
Results First Posted
March 26, 2012
Record last verified: 2013-01