NCT01500499

Brief Summary

RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies the role of biomarkers in disease progression in samples from patients with acute myeloid leukemia.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2011

Completed
23 days until next milestone

First Submitted

Initial submission to the registry

December 24, 2011

Completed
4 days until next milestone

First Posted

Study publicly available on registry

December 28, 2011

Completed
4.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2016

Completed
Last Updated

May 18, 2016

Status Verified

May 1, 2016

Enrollment Period

4.4 years

First QC Date

December 24, 2011

Last Update Submit

May 17, 2016

Conditions

Leukemia

Keywords

adult acute myeloid leukemiachildhood acute myeloid leukemia/other myeloid malignancies

Outcome Measures

Primary Outcomes (1)

  • Subcellular localization of the MLL-AF1q fusion protein in leukemia cells

Interventions

gene expression analysisGENETIC
gene rearrangement analysisGENETIC
polymerase chain reactionGENETIC
protein analysisGENETIC
western blottingGENETIC
laboratory biomarker analysisOTHER
mass spectrometryOTHER

Eligibility Criteria

AgeUp to 30 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Acute myeloid leukemia.

DISEASE CHARACTERISTICS: * Cryopreserved acute myeloid leukemia specimens PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

MeSH Terms

Conditions

LeukemiaLeukemia, Myeloid, Acute

Interventions

Gene Expression ProfilingGene RearrangementPolymerase Chain ReactionBlotting, WesternMass Spectrometry

Condition Hierarchy (Ancestors)

Neoplasms by Histologic TypeNeoplasmsHematologic DiseasesHemic and Lymphatic DiseasesLeukemia, Myeloid

Intervention Hierarchy (Ancestors)

Genetic TechniquesInvestigative TechniquesGenetic PhenomenaNucleic Acid Amplification TechniquesElectrophoresisChemistry Techniques, AnalyticalElectrochemical TechniquesImmunoblottingImmunoassayImmunologic TechniquesMolecular Probe Techniques

Study Officials

  • Julie D. Saba, MD, PhD

    UCSF Benioff Children's Hospital Oakland

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
RETROSPECTIVE
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 24, 2011

First Posted

December 28, 2011

Study Start

December 1, 2011

Primary Completion

May 1, 2016

Last Updated

May 18, 2016

Record last verified: 2016-05