Biomarkers in Samples From Younger Patients With Wilms Tumor

NCT01493817 | Completed

• 2 other identifiers: AREN12B1NCI-2012-00093
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This research study is studying biomarkers in tissue samples from younger patients with Wilms tumor. Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors predict how patients respond to treatment

Conditions

Wilms Tumor and Other Childhood Kidney Tumors

Outcome Measures

Primary Outcomes (1)

• Relationship of tumor-associated macrophages and prognosis

  Correlation of each type of macrophage score with tumor staging, presence of vascular invasion, and disease-free survival will be assessed.

  1 month

Study Arms (1)

Basic science (biomarker analysis)

Paraffin-embedded specimens are analyzed for macrophage markers. Results of each sample are then compared with patient's tumor stage, presence of vascular invasion, tumor progression, and survival.

Other: laboratory biomarker analysis

Interventions

laboratory biomarker analysis OTHER

Correlative studies

Basic science (biomarker analysis)

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Wilms tumor patients

You may qualify if:

• Wilms tissue microarray samples provided by the Children's Oncology Group

Sponsors & Collaborators

• Children's Oncology Group: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

Children's Oncology Group

Monrovia, California, 91006-3776, United States

Location

MeSH Terms

Conditions

Wilms Tumor

Condition Hierarchy (Ancestors)

Neoplasms, Complex and Mixed; Neoplasms by Histologic Type; Neoplasms; Kidney Neoplasms; Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Neoplastic Syndromes, Hereditary; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Jessica Kandel, MD

  Children's Oncology Group

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2011
• First Posted: December 16, 2011
• Study Start: December 1, 2011
• Primary Completion: May 1, 2016
• Last Updated: May 19, 2016

Record last verified: 2016-05

Locations

US (1)